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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for STK25 |
 Gene summary |
| Gene information | Gene symbol | STK25 | Gene ID | 10494 |
| Gene name | serine/threonine kinase 25 | |
| Synonyms | SOK1|YSK1 | |
| Cytomap | 2q37.3 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 25Ste20, yeast homologste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1 | |
| Modification date | 20200313 | |
| UniProtAcc | O00506, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK25 | GO:0006468 | protein phosphorylation | 17657516 |
| STK25 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
| STK25 | GO:0042542 | response to hydrogen peroxide | 22291017 |
| STK25 | GO:0046777 | protein autophosphorylation | 17657516 |
| STK25 | GO:0051645 | Golgi localization | 15037601 |
Top |
RNA A-to-I events for STK25 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_857992(241501950, -), ADediting_857993(241502078, -), ADediting_857994(241502125, -), ADediting_857995(241502550, -), ADediting_857996(241502572, -), ADediting_857997(241502609, -), ADediting_857998(241502615, -), ADediting_857999(241502627, -), ADediting_858000(241502630, -), ADediting_858001(241502631, -), ADediting_858002(241502656, -), ADediting_858003(241502676, -), ADediting_858004(241502677, -), ADediting_858005(241502682, -), ADediting_858006(241502692, -), ADediting_858007(241502738, -), ADediting_858008(241503097, -), ADediting_858009(241503099, -), ADediting_858010(241503118, -), ADediting_858011(241503149, -), ADediting_858012(241503170, -), ADediting_858013(241503172, -), ADediting_858014(241503175, -), ADediting_858015(241503192, -), ADediting_858016(241503201, -), ADediting_858017(241503202, -), ADediting_858018(241503228, -), ADediting_858019(241503231, -), ADediting_858020(241503232, -), ADediting_858021(241503233, -), ADediting_858022(241503234, -), ADediting_858023(241503235, -), ADediting_858024(241503238, -), ADediting_858025(241503243, -), ADediting_858026(241503244, -), ADediting_858027(241503268, -), ADediting_858028(241503269, -), ADediting_858029(241503278, -), ADediting_858030(241503296, -), ADediting_858031(241503332, -), ADediting_858032(241503337, -), ADediting_858033(241503338, -), ADediting_858034(241503456, -), ADediting_858035(241503468, -), ADediting_858036(241503469, -), ADediting_858037(241503470, -), ADediting_858038(241503523, -), ADediting_858039(241503531, -), ADediting_858040(241503545, -), ADediting_858041(241503548, -), ADediting_858042(241503564, -), ADediting_858043(241503573, -), ADediting_858044(241503601, -), ADediting_858045(241503613, -), ADediting_858046(241503623, -), ADediting_858047(241503659, -), ADediting_858048(241503689, -), ADediting_858049(241504898, -), ADediting_858050(241504979, -), ADediting_858051(241504993, -), ADediting_858052(241505013, -), ADediting_858053(241505014, -), ADediting_858054(241505022, -), ADediting_858055(241505025, -), ADediting_858056(241505045, -), ADediting_858057(241505080, -), ADediting_858058(241505081, -), ADediting_858059(241505087, -), ADediting_858060(241505088, -), ADediting_858061(241505089, -), ADediting_858062(241505090, -), ADediting_858063(241505118, -), ADediting_858064(241505128, -), ADediting_858065(241506565, -), ADediting_858067(241506645, -), ADediting_858068(241506655, -), ADediting_858069(241506658, -), ADediting_858070(241506659, -), ADediting_858071(241506684, -), ADediting_858072(241506687, -), ADediting_858073(241506690, -), ADediting_858074(241506715, -), ADediting_858075(241506728, -), ADediting_1562884(241501976, -), ADediting_1562885(241502617, -), ADediting_1562886(241502661, -), ADediting_1562887(241502700, -), ADediting_1562888(241503132, -), ADediting_1562889(241503140, -), ADediting_1562890(241503247, -), ADediting_1562891(241503565, -), ADediting_1562892(241503695, -), |
Top |
RNA editing positional annotations for STK25 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_857992 | chr2_241501950_- | UTR5 |
| ADediting_857993 | chr2_241502078_- | intronic |
| ADediting_857994 | chr2_241502125_- | intronic |
| ADediting_857995 | chr2_241502550_- | intronic |
| ADediting_857996 | chr2_241502572_- | intronic |
| ADediting_857997 | chr2_241502609_- | intronic |
| ADediting_857998 | chr2_241502615_- | intronic |
| ADediting_857999 | chr2_241502627_- | intronic |
| ADediting_858000 | chr2_241502630_- | intronic |
| ADediting_858001 | chr2_241502631_- | intronic |
| ADediting_858002 | chr2_241502656_- | intronic |
| ADediting_858003 | chr2_241502676_- | intronic |
| ADediting_858004 | chr2_241502677_- | intronic |
| ADediting_858005 | chr2_241502682_- | intronic |
| ADediting_858006 | chr2_241502692_- | intronic |
| ADediting_858007 | chr2_241502738_- | intronic |
| ADediting_858008 | chr2_241503097_- | intronic |
| ADediting_858009 | chr2_241503099_- | intronic |
| ADediting_858010 | chr2_241503118_- | intronic |
| ADediting_858011 | chr2_241503149_- | intronic |
| ADediting_858012 | chr2_241503170_- | intronic |
| ADediting_858013 | chr2_241503172_- | intronic |
| ADediting_858014 | chr2_241503175_- | intronic |
| ADediting_858015 | chr2_241503192_- | intronic |
| ADediting_858016 | chr2_241503201_- | intronic |
| ADediting_858017 | chr2_241503202_- | intronic |
| ADediting_858018 | chr2_241503228_- | intronic |
| ADediting_858019 | chr2_241503231_- | intronic |
| ADediting_858020 | chr2_241503232_- | intronic |
| ADediting_858021 | chr2_241503233_- | intronic |
| ADediting_858022 | chr2_241503234_- | intronic |
| ADediting_858023 | chr2_241503235_- | intronic |
| ADediting_858024 | chr2_241503238_- | intronic |
| ADediting_858025 | chr2_241503243_- | intronic |
| ADediting_858026 | chr2_241503244_- | intronic |
| ADediting_858027 | chr2_241503268_- | intronic |
| ADediting_858028 | chr2_241503269_- | intronic |
| ADediting_858029 | chr2_241503278_- | intronic |
| ADediting_858030 | chr2_241503296_- | intronic |
| ADediting_858031 | chr2_241503332_- | intronic |
| ADediting_858032 | chr2_241503337_- | intronic |
| ADediting_858033 | chr2_241503338_- | intronic |
| ADediting_858034 | chr2_241503456_- | intronic |
| ADediting_858035 | chr2_241503468_- | intronic |
| ADediting_858036 | chr2_241503469_- | intronic |
| ADediting_858037 | chr2_241503470_- | intronic |
| ADediting_858038 | chr2_241503523_- | intronic |
| ADediting_858039 | chr2_241503531_- | intronic |
| ADediting_858040 | chr2_241503545_- | intronic |
| ADediting_858041 | chr2_241503548_- | intronic |
| ADediting_858042 | chr2_241503564_- | intronic |
| ADediting_858043 | chr2_241503573_- | intronic |
| ADediting_858044 | chr2_241503601_- | intronic |
| ADediting_858045 | chr2_241503613_- | intronic |
| ADediting_858046 | chr2_241503623_- | intronic |
| ADediting_858047 | chr2_241503659_- | intronic |
| ADediting_858048 | chr2_241503689_- | intronic |
| ADediting_858049 | chr2_241504898_- | intronic |
| ADediting_858050 | chr2_241504979_- | intronic |
| ADediting_858051 | chr2_241504993_- | intronic |
| ADediting_858052 | chr2_241505013_- | intronic |
| ADediting_858053 | chr2_241505014_- | intronic |
| ADediting_858054 | chr2_241505022_- | intronic |
| ADediting_858055 | chr2_241505025_- | intronic |
| ADediting_858056 | chr2_241505045_- | intronic |
| ADediting_858057 | chr2_241505080_- | intronic |
| ADediting_858058 | chr2_241505081_- | intronic |
| ADediting_858059 | chr2_241505087_- | intronic |
| ADediting_858060 | chr2_241505088_- | intronic |
| ADediting_858061 | chr2_241505089_- | intronic |
| ADediting_858062 | chr2_241505090_- | intronic |
| ADediting_858063 | chr2_241505118_- | intronic |
| ADediting_858064 | chr2_241505128_- | intronic |
| ADediting_858065 | chr2_241506565_- | intronic |
| ADediting_858067 | chr2_241506645_- | intronic |
| ADediting_858068 | chr2_241506655_- | intronic |
| ADediting_858069 | chr2_241506658_- | intronic |
| ADediting_858070 | chr2_241506659_- | intronic |
| ADediting_858071 | chr2_241506684_- | intronic |
| ADediting_858072 | chr2_241506687_- | intronic |
| ADediting_858073 | chr2_241506690_- | intronic |
| ADediting_858074 | chr2_241506715_- | intronic |
| ADediting_858075 | chr2_241506728_- | intronic |
| ADediting_1562884 | chr2_241501976_- | UTR5 |
| ADediting_1562885 | chr2_241502617_- | intronic |
| ADediting_1562886 | chr2_241502661_- | intronic |
| ADediting_1562887 | chr2_241502700_- | intronic |
| ADediting_1562888 | chr2_241503132_- | intronic |
| ADediting_1562889 | chr2_241503140_- | intronic |
| ADediting_1562890 | chr2_241503247_- | intronic |
| ADediting_1562891 | chr2_241503565_- | intronic |
| ADediting_1562892 | chr2_241503695_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_857992 | chr2_241501950_- | SINE | Alu | Name=AluSq2 |
| ADediting_857993 | chr2_241502078_- | SINE | Alu | Name=AluSq2 |
| ADediting_857994 | chr2_241502125_- | SINE | Alu | Name=AluSq2 |
| ADediting_857995 | chr2_241502550_- | SINE | Alu | Name=AluSp |
| ADediting_857996 | chr2_241502572_- | SINE | Alu | Name=AluSp |
| ADediting_857997 | chr2_241502609_- | SINE | Alu | Name=AluSp |
| ADediting_857998 | chr2_241502615_- | SINE | Alu | Name=AluSp |
| ADediting_857999 | chr2_241502627_- | SINE | Alu | Name=AluSp |
| ADediting_858000 | chr2_241502630_- | SINE | Alu | Name=AluSp |
| ADediting_858001 | chr2_241502631_- | SINE | Alu | Name=AluSp |
| ADediting_858002 | chr2_241502656_- | SINE | Alu | Name=AluSp |
| ADediting_858003 | chr2_241502676_- | SINE | Alu | Name=AluSp |
| ADediting_858004 | chr2_241502677_- | SINE | Alu | Name=AluSp |
| ADediting_858005 | chr2_241502682_- | SINE | Alu | Name=AluSp |
| ADediting_858006 | chr2_241502692_- | SINE | Alu | Name=AluSp |
| ADediting_858007 | chr2_241502738_- | SINE | Alu | Name=AluSp |
| ADediting_858008 | chr2_241503097_- | SINE | Alu | Name=AluSx |
| ADediting_858009 | chr2_241503099_- | SINE | Alu | Name=AluSx |
| ADediting_858010 | chr2_241503118_- | SINE | Alu | Name=AluSx |
| ADediting_858011 | chr2_241503149_- | SINE | Alu | Name=AluSx |
| ADediting_858012 | chr2_241503170_- | SINE | Alu | Name=AluSx |
| ADediting_858013 | chr2_241503172_- | SINE | Alu | Name=AluSx |
| ADediting_858014 | chr2_241503175_- | SINE | Alu | Name=AluSx |
| ADediting_858015 | chr2_241503192_- | SINE | Alu | Name=AluSx |
| ADediting_858016 | chr2_241503201_- | SINE | Alu | Name=AluSx |
| ADediting_858017 | chr2_241503202_- | SINE | Alu | Name=AluSx |
| ADediting_858018 | chr2_241503228_- | SINE | Alu | Name=AluSx |
| ADediting_858019 | chr2_241503231_- | SINE | Alu | Name=AluSx |
| ADediting_858020 | chr2_241503232_- | SINE | Alu | Name=AluSx |
| ADediting_858021 | chr2_241503233_- | SINE | Alu | Name=AluSx |
| ADediting_858022 | chr2_241503234_- | SINE | Alu | Name=AluSx |
| ADediting_858023 | chr2_241503235_- | SINE | Alu | Name=AluSx |
| ADediting_858024 | chr2_241503238_- | SINE | Alu | Name=AluSx |
| ADediting_858025 | chr2_241503243_- | SINE | Alu | Name=AluSx |
| ADediting_858026 | chr2_241503244_- | SINE | Alu | Name=AluSx |
| ADediting_858027 | chr2_241503268_- | SINE | Alu | Name=AluSx |
| ADediting_858028 | chr2_241503269_- | SINE | Alu | Name=AluSx |
| ADediting_858029 | chr2_241503278_- | SINE | Alu | Name=AluSx |
| ADediting_858030 | chr2_241503296_- | SINE | Alu | Name=AluSx |
| ADediting_858031 | chr2_241503332_- | SINE | Alu | Name=AluSx |
| ADediting_858032 | chr2_241503337_- | SINE | Alu | Name=AluSx |
| ADediting_858033 | chr2_241503338_- | SINE | Alu | Name=AluSx |
| ADediting_858034 | chr2_241503456_- | SINE | Alu | Name=AluY |
| ADediting_858035 | chr2_241503468_- | SINE | Alu | Name=AluY |
| ADediting_858036 | chr2_241503469_- | SINE | Alu | Name=AluY |
| ADediting_858037 | chr2_241503470_- | SINE | Alu | Name=AluY |
| ADediting_858038 | chr2_241503523_- | SINE | Alu | Name=AluY |
| ADediting_858039 | chr2_241503531_- | SINE | Alu | Name=AluY |
| ADediting_858040 | chr2_241503545_- | SINE | Alu | Name=AluY |
| ADediting_858041 | chr2_241503548_- | SINE | Alu | Name=AluY |
| ADediting_858042 | chr2_241503564_- | SINE | Alu | Name=AluY |
| ADediting_858043 | chr2_241503573_- | SINE | Alu | Name=AluY |
| ADediting_858044 | chr2_241503601_- | SINE | Alu | Name=AluY |
| ADediting_858045 | chr2_241503613_- | SINE | Alu | Name=AluY |
| ADediting_858046 | chr2_241503623_- | SINE | Alu | Name=AluY |
| ADediting_858047 | chr2_241503659_- | SINE | Alu | Name=AluY |
| ADediting_858048 | chr2_241503689_- | SINE | Alu | Name=AluY |
| ADediting_858050 | chr2_241504979_- | SINE | Alu | Name=AluSx1 |
| ADediting_858051 | chr2_241504993_- | SINE | Alu | Name=AluSx1 |
| ADediting_858052 | chr2_241505013_- | SINE | Alu | Name=AluSx1 |
| ADediting_858053 | chr2_241505014_- | SINE | Alu | Name=AluSx1 |
| ADediting_858054 | chr2_241505022_- | SINE | Alu | Name=AluSx1 |
| ADediting_858055 | chr2_241505025_- | SINE | Alu | Name=AluSx1 |
| ADediting_858056 | chr2_241505045_- | SINE | Alu | Name=AluSx1 |
| ADediting_858057 | chr2_241505080_- | SINE | Alu | Name=AluSx1 |
| ADediting_858058 | chr2_241505081_- | SINE | Alu | Name=AluSx1 |
| ADediting_858059 | chr2_241505087_- | SINE | Alu | Name=AluSx1 |
| ADediting_858060 | chr2_241505088_- | SINE | Alu | Name=AluSx1 |
| ADediting_858061 | chr2_241505089_- | SINE | Alu | Name=AluSx1 |
| ADediting_858062 | chr2_241505090_- | SINE | Alu | Name=AluSx1 |
| ADediting_858063 | chr2_241505118_- | SINE | Alu | Name=AluSx1 |
| ADediting_858064 | chr2_241505128_- | SINE | Alu | Name=AluSx1 |
| ADediting_858065 | chr2_241506565_- | SINE | Alu | Name=AluSq2 |
| ADediting_858067 | chr2_241506645_- | SINE | Alu | Name=AluSq2 |
| ADediting_858068 | chr2_241506655_- | SINE | Alu | Name=AluSq2 |
| ADediting_858069 | chr2_241506658_- | SINE | Alu | Name=AluSq2 |
| ADediting_858070 | chr2_241506659_- | SINE | Alu | Name=AluSq2 |
| ADediting_858071 | chr2_241506684_- | SINE | Alu | Name=AluSq2 |
| ADediting_858072 | chr2_241506687_- | SINE | Alu | Name=AluSq2 |
| ADediting_858073 | chr2_241506690_- | SINE | Alu | Name=AluSq2 |
| ADediting_858074 | chr2_241506715_- | SINE | Alu | Name=AluSq2 |
| ADediting_858075 | chr2_241506728_- | SINE | Alu | Name=AluSq2 |
| ADediting_1562884 | chr2_241501976_- | SINE | Alu | Name=AluSq2 |
| ADediting_1562885 | chr2_241502617_- | SINE | Alu | Name=AluSp |
| ADediting_1562886 | chr2_241502661_- | SINE | Alu | Name=AluSp |
| ADediting_1562887 | chr2_241502700_- | SINE | Alu | Name=AluSp |
| ADediting_1562888 | chr2_241503132_- | SINE | Alu | Name=AluSx |
| ADediting_1562889 | chr2_241503140_- | SINE | Alu | Name=AluSx |
| ADediting_1562890 | chr2_241503247_- | SINE | Alu | Name=AluSx |
| ADediting_1562891 | chr2_241503565_- | SINE | Alu | Name=AluY |
| ADediting_1562892 | chr2_241503695_- | SINE | Alu | Name=AluY |
Top |
RNA A-to-I editing events in the alternative splicing sites for STK25 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for STK25 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for STK25 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for STK25 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-589-3p | chr2 | 241494474 | 241494480 | 7mer-m8 | 241494473 | 241494497 | 141 | -21.47 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-4512 | chr2 | 241494625 | 241494631 | 7mer-m8 | 241494624 | 241494648 | 157 | -23.74 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000401869.5 | STK25-202 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000403346.7 | STK25-203 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000405883.7 | STK25-205 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000535007.5 | STK25-234 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| ADediting_496066 | chr15_66496985_- | ENSG00000115694.15 | ENST00000543554.5 | STK25-235 | hsa-miR-4512 | chr2 | 241495050 | 241495056 | 7mer-m8 | 241495049 | 241495070 | 152 | -18.13 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-5688 | chr2 | 241494823 | 241494829 | 7mer-m8 | 241494822 | 241494843 | 147 | -9.69 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000401869.5 | STK25-202 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000403346.7 | STK25-203 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000405585.5 | STK25-204 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000405883.7 | STK25-205 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000535007.5 | STK25-234 | hsa-miR-5688 | chr2 | 241494823 | 241494829 | 7mer-m8 | 241494822 | 241494843 | 147 | -9.69 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000535007.5 | STK25-234 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000543554.5 | STK25-235 | hsa-miR-5688 | chr2 | 241494823 | 241494829 | 7mer-m8 | 241494822 | 241494843 | 147 | -9.69 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000115694.15 | ENST00000543554.5 | STK25-235 | hsa-miR-5688 | chr2 | 241495621 | 241495627 | 7mer-m8 | 241495620 | 241495642 | 151 | -13.19 |
| ADediting_291761 | chr11_93733708_- | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-1304-3p | chr2 | 241493976 | 241493982 | 7mer-m8 | 241493975 | 241493996 | 140 | -14.67 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000115694.15 | ENST00000316586.9 | STK25-201 | hsa-miR-4775 | chr2 | 241493446 | 241493452 | 7mer-m8 | 241493445 | 241493466 | 140 | -7.08 |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for STK25 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000435225.5 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_857992 | ENST00000435225.5 | chr2_241501950_- | 54 | -188.90 | -186.80 | -190.30 |
| ADediting_1562884 | ENST00000435225.5 | chr2_241501976_- | 28 | -187.60 | -186.80 | -190.30 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for STK25 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_857993 | chr2_241502078_- | 0.0658562238569086 | 0.150588586846021 | 3.28529986340089e-05 | 0.332169334909192 | 0.205891689155594 | 0.103871491979923 |
| CER | ADediting_857994 | chr2_241502125_- | 0.0344487754374506 | 0.172815322644736 | 0.000124719300061573 | 0.308180443847014 | 0.0453856868699739 | 0.163651833668907 |
| CER | ADediting_857995 | chr2_241502550_- | 0.000887625710015667 | 0.268637508957195 | 5.71645234668749e-08 | 0.42546635707173 | 0.0618457339350523 | 0.152854022872609 |
| CER | ADediting_858003 | chr2_241502676_- | 0.0008966701629616 | 0.268417370201118 | 5.84468324937256e-08 | 0.425185724101052 | 0.0313715461120467 | 0.175836182161205 |
| CER | ADediting_858034 | chr2_241503456_- | 0.00222779634947441 | 0.247854486271227 | 1.07848770541639e-05 | 0.350774202224722 | 0.024349268094466 | 0.183808560687937 |
| CER | ADediting_858035 | chr2_241503468_- | 0.000186234702783152 | 0.300552913978859 | 1.07092675834461e-06 | 0.385981882991592 | 0.00215376133984781 | 0.24864832549979 |
| CER | ADediting_858047 | chr2_241503659_- | 0.129595878690943 | 0.124315550848687 | 2.05623534843281e-05 | 0.340140970390996 | 0.658673325738781 | 0.0363606171408406 |
| CER | ADediting_858073 | chr2_241506690_- | 0.0763454762691794 | 0.145154222068297 | 0.000105526729119046 | 0.311298931428412 | 0.0616312264373437 | 0.152978544642614 |
| CER | ADediting_858074 | chr2_241506715_- | 0.0129177431677718 | 0.202569020858806 | 1.20961673666474e-06 | 0.38422506613445 | 0.00389391701522886 | 0.234361265457298 |
| CER | ADediting_858075 | chr2_241506728_- | 0.106883765071025 | 0.132176032500805 | 9.03547514078361e-05 | 0.31416504225171 | 0.0005694617808609 | 0.278100354860923 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 6.82611585408414e-33 | 0.609314970436349 | 1.18696277548787e-40 | 0.66320134762428 | 1.25255941020794e-22 | 0.517439805089559 |
| AC | 4.4353216141042e-78 | 0.869882337468632 | 1.4281852623056e-63 | 0.825592765693576 | 1.63758723915129e-15 | 0.475560662048147 |
| PCC | 6.57719716249888e-36 | 0.750993606814896 | 1.87230589413359e-37 | 0.761607231570405 | 0.00635369927522877 | 0.196816456874333 |
| CER | 3.3975595743246e-09 | 0.459249076952351 | 1.50328470142459e-05 | 0.345350370092597 | 0.76484320286711 | -0.0246259136568645 |
| TCX | 2.04697560439435e-21 | 0.676597615457136 | 1.25789234653301e-18 | 0.639587405769455 | 0.322839665045613 | 0.081268292301168 |
| FP | 6.26194426355012e-29 | 0.712916487318655 | 1.62304167028734e-28 | 0.709174198563358 | 3.74833489783112e-06 | 0.338731805625331 |
| IFG | 1.74041806795489e-08 | 0.869092888899773 | 2.00432870377189e-08 | 0.86737443877019 | 0.109849917953554 | 0.32764892239946 |
| PG | 0.00010471329324755 | 0.280606905978995 | 9.73654991942889e-06 | 0.317991593105864 | 0.0987031133052464 | 0.121440081468239 |
| STG | 3.14445976155277e-26 | 0.864583636790454 | 5.95438672926505e-14 | 0.70655912344349 | 0.0481313067591193 | 0.21630300236124 |
Top |
Relation with AD stages for STK25 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_857995 | chr2_241502550_- | 0.000135430662473314 | 0.359082377358136 |
| CER | ADediting_858003 | chr2_241502676_- | 0.000126352312513608 | 0.360581541669069 |
| CER | ADediting_858034 | chr2_241503456_- | 0.000653482958991313 | 0.322898107548087 |
| CER | ADediting_858035 | chr2_241503468_- | 8.32276042902012e-05 | 0.369449385366555 |
| CER | ADediting_858036 | chr2_241503469_- | 0.000582804862543612 | 0.325683530019165 |
| CER | ADediting_858065 | chr2_241506565_- | 0.000611372267482947 | 0.324522247599725 |
| CER | ADediting_858073 | chr2_241506690_- | 0.000189377789970022 | 0.351731718197294 |
| CER | ADediting_858074 | chr2_241506715_- | 2.42974340980416e-05 | 0.394200579853937 |
| CER | ADediting_858075 | chr2_241506728_- | 4.93950628411972e-05 | 0.380181551990083 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
Top |
RelatedDrugs for STK25 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for STK25 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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