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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for SPACA6P-AS |
 Gene summary |
| Gene information | Gene symbol | SPACA6P-AS | Gene ID | 102238594 |
| Gene name | SPACA6P antisense RNA | |
| Synonyms | LINC01129 | |
| Cytomap | 19q13.41 | |
| Type of gene | ncRNA | |
| Description | long intergenic non-protein coding RNA 1129 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for SPACA6P-AS |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_776189(51685610, -), ADediting_776190(51685754, -), ADediting_776191(51685763, -), ADediting_776192(51685768, -), ADediting_776193(51685843, -), ADediting_776194(51687179, -), ADediting_1557801(51685637, -), |
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RNA editing positional annotations for SPACA6P-AS using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_776189 | chr19_51685610_- | ncRNA_exonic |
| ADediting_776190 | chr19_51685754_- | ncRNA_exonic |
| ADediting_776191 | chr19_51685763_- | ncRNA_exonic |
| ADediting_776192 | chr19_51685768_- | ncRNA_exonic |
| ADediting_776193 | chr19_51685843_- | ncRNA_exonic |
| ADediting_776194 | chr19_51687179_- | ncRNA_exonic |
| ADediting_1557801 | chr19_51685637_- | ncRNA_exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_776189 | chr19_51685610_- | SINE | Alu | Name=AluJb |
| ADediting_776190 | chr19_51685754_- | SINE | Alu | Name=AluJb |
| ADediting_776191 | chr19_51685763_- | SINE | Alu | Name=AluJb |
| ADediting_776192 | chr19_51685768_- | SINE | Alu | Name=AluJb |
| ADediting_776193 | chr19_51685843_- | DNA | TcMar-Tigger | Name=Tigger4b |
| ADediting_776194 | chr19_51687179_- | SINE | Alu | Name=AluSz |
| ADediting_1557801 | chr19_51685637_- | SINE | Alu | Name=AluJb |
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RNA A-to-I editing events in the alternative splicing sites for SPACA6P-AS |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPACA6P-AS |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for SPACA6P-AS |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for SPACA6P-AS |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1557801 | chr19_51685637_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-2355-5p | chr19 | 51685633 | 51685639 | 7mer-m8 | 51685632 | 51685651 | 144 | -17.06 |
| ADediting_776189 | chr19_51685610_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4437 | chr19 | 51685604 | 51685611 | 8mer-1a | 51685604 | 51685624 | 146 | -19.59 |
| ADediting_776193 | chr19_51685843_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-6884-3p | chr19 | 51685841 | 51685848 | 8mer-1a | 51685841 | 51685863 | 142 | -10.03 |
| ADediting_776193 | chr19_51685843_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-7151-5p | chr19 | 51685840 | 51685846 | 7mer-m8 | 51685839 | 51685862 | 143 | -12.72 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1557801 | chr19_51685637_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-325 | chr19 | 51685636 | 51685642 | 7mer-m8 | 51685635 | 51685658 | 148 | -19.07 |
| ADediting_776189 | chr19_51685610_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-27a-5p | chr19 | 51685604 | 51685611 | 8mer-1a | 51685604 | 51685625 | 145 | -15.5 |
| ADediting_776189 | chr19_51685610_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4503 | chr19 | 51685609 | 51685615 | 7mer-m8 | 51685608 | 51685629 | 141 | -10.72 |
| ADediting_776189 | chr19_51685610_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4720-3p | chr19 | 51685607 | 51685613 | 7mer-m8 | 51685606 | 51685626 | 146 | -12.01 |
| ADediting_776190 | chr19_51685754_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-1245a | chr19 | 51685752 | 51685758 | 7mer-m8 | 51685751 | 51685771 | 149 | -18.39 |
| ADediting_776191 | chr19_51685763_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-1976 | chr19 | 51685759 | 51685765 | 7mer-m8 | 51685758 | 51685779 | 152 | -25.54 |
| ADediting_776191 | chr19_51685763_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-660-3p | chr19 | 51685757 | 51685764 | 8mer-1a | 51685757 | 51685777 | 143 | -15.8 |
| ADediting_776191 | chr19_51685763_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-6747-3p | chr19 | 51685760 | 51685767 | 8mer-1a | 51685760 | 51685782 | 154 | -25.82 |
| ADediting_776194 | chr19_51687179_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-135a-5p | chr19 | 51687174 | 51687180 | 7mer-m8 | 51687173 | 51687195 | 140 | -11.38 |
| ADediting_776194 | chr19_51687179_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-135b-5p | chr19 | 51687174 | 51687180 | 7mer-m8 | 51687173 | 51687195 | 140 | -12.01 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-589-3p | chr19 | 51686628 | 51686634 | 7mer-m8 | 51686627 | 51686648 | 159 | -27.41 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-589-3p | chr19 | 51693403 | 51693409 | 7mer-m8 | 51693402 | 51693424 | 150 | -17.49 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4477b | chr19 | 51686333 | 51686339 | 7mer-m8 | 51686332 | 51686355 | 154 | -22.29 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4477b | chr19 | 51692813 | 51692819 | 7mer-m8 | 51692812 | 51692833 | 140 | -13.15 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-641 | chr19 | 51693291 | 51693297 | 7mer-m8 | 51693290 | 51693310 | 153 | -20.78 |
| ADediting_496066 | chr15_66496985_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4512 | chr19 | 51687986 | 51687992 | 7mer-m8 | 51687985 | 51688005 | 154 | -26.15 |
| ADediting_496066 | chr15_66496985_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4512 | chr19 | 51692639 | 51692645 | 7mer-m8 | 51692638 | 51692659 | 152 | -28.97 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4775 | chr19 | 51685368 | 51685375 | 8mer-1a | 51685368 | 51685390 | 159 | -9.8 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4775 | chr19 | 51685912 | 51685919 | 8mer-1a | 51685912 | 51685936 | 148 | -11.72 |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-589-3p | chr19 | 51686155 | 51686161 | 7mer-m8 | 51686154 | 51686177 | 154 | -15.52 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4477b | chr19 | 51685948 | 51685954 | 7mer-m8 | 51685947 | 51685973 | 150 | -16.04 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4477b | chr19 | 51685948 | 51685954 | 7mer-m8 | 51685947 | 51685973 | 150 | -16.04 |
| ADediting_496066 | chr15_66496985_- | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4512 | chr19 | 51688312 | 51688318 | 7mer-m8 | 51688311 | 51688332 | 151 | -14.01 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000269959.1 | ENST00000602324.1 | SPACA6P-AS-201 | hsa-miR-4775 | chr19 | 51685504 | 51685510 | 7mer-m8 | 51685503 | 51685524 | 144 | -3.33 |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
| Differentially expressed lncRNA-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for SPACA6P-AS |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000602324.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_776189 | ENST00000602324.1 | chr19_51685610_- | 3715 | -1429.70 | -1423.30 | -1439.80 |
| ADediting_1557801 | ENST00000602324.1 | chr19_51685637_- | 3688 | -1423.70 | -1423.30 | -1439.80 |
| ADediting_776190 | ENST00000602324.1 | chr19_51685754_- | 3571 | -1422.90 | -1423.30 | -1439.80 |
| ADediting_776191 | ENST00000602324.1 | chr19_51685763_- | 3562 | -1428.00 | -1423.30 | -1439.80 |
| ADediting_776192 | ENST00000602324.1 | chr19_51685768_- | 3557 | -1422.60 | -1423.30 | -1439.80 |
| ADediting_776193 | ENST00000602324.1 | chr19_51685843_- | 3482 | -1429.90 | -1423.30 | -1439.80 |
| ADediting_776194 | ENST00000602324.1 | chr19_51687179_- | 2146 | -1423.00 | -1423.30 | -1439.80 |
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Relation with ADAR for SPACA6P-AS |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_776189 | chr19_51685610_- | 0.0724982655876277 | 0.102150286556471 | 0.594661954548193 | -0.0303364164657266 | 8.41428693552487e-12 | 0.375239041467839 |
| CER | ADediting_776190 | chr19_51685754_- | 0.0278447643337402 | 0.179625057589891 | 0.000111753918820412 | 0.31023283006348 | 0.969037989026858 | 0.00319594849224602 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.17262853824755e-07 | 0.275738998186299 | 0.000389182783683011 | 0.200238485337599 | 3.51917065875889e-14 | 0.412711729426799 |
| AC | 1.35229778340457e-05 | 0.271388455209362 | 7.23673507682044e-05 | 0.248284533685322 | 6.11317683121261e-07 | 0.309228398370419 |
| CER | 2.29195825807733e-06 | 0.374833871156671 | 2.35475092979281e-15 | 0.588593904479311 | 0.01690132686175 | 0.194805757161623 |
| TCX | 0.290956590602568 | 0.0867873248254391 | 0.348791292050468 | -0.0770311921927017 | 1.30755191623809e-06 | 0.383096571195991 |
| FP | 0.000905608375743461 | 0.24660343655046 | 1.28168772613841e-06 | 0.353658508408415 | 2.40208319547788e-09 | 0.428564978097316 |
| IFG | 0.00552726573559342 | 0.538091981515146 | 0.00036429092411282 | 0.656573071668583 | 0.00552143583563146 | 0.538147779940569 |
| PG | 4.44396745294719e-11 | 0.458962900410172 | 4.19806031466951e-11 | 0.459484407117914 | 0.346961458080495 | 0.0693451817957807 |
| STG | 0.789392666783349 | -0.0295797714203358 | 0.436005621842765 | 0.0861234471110977 | 0.00300493935575004 | 0.319988116830208 |
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Relation with AD stages for SPACA6P-AS |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.0671218587275e-07 | 0.461238934651554 |
| TCX | 0.000143852650262132 | 0.360979179724537 |
| IFG | 0.039657322370185 | 0.413985828555778 |
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RelatedDrugs for SPACA6P-AS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPACA6P-AS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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