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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for RNF41

check button Gene summary
Gene informationGene symbol

RNF41

Gene ID

10193

Gene namering finger protein 41
SynonymsFLRF|NRDP1|SBBI03
Cytomap

12q13.3

Type of geneprotein-coding
DescriptionE3 ubiquitin-protein ligase NRDP1RING-type E3 ubiquitin transferase NRDP1fetal liver ring fingerneuregulin receptor degradation protein-1ring finger protein 41, E3 ubiquitin protein ligase
Modification date20200313
UniProtAcc

Q9H4P4,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
RNF41

GO:0000209

protein polyubiquitination

14765125|18541373

RNF41

GO:0008285

negative regulation of cell proliferation

17145873

RNF41

GO:0010498

proteasomal protein catabolic process

18541373

RNF41

GO:0043408

regulation of MAPK cascade

17145873

RNF41

GO:0051865

protein autoubiquitination

24105792

RNF41

GO:0051896

regulation of protein kinase B signaling

17145873

RNF41

GO:0097191

extrinsic apoptotic signaling pathway

14765125


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RNA A-to-I events for RNF41

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_357568(56203280, -), ADediting_357569(56203300, -), ADediting_357570(56203324, -), ADediting_357571(56203513, -), ADediting_357572(56203802, -), ADediting_357573(56203817, -), ADediting_357574(56203834, -), ADediting_357575(56203844, -), ADediting_357576(56203870, -), ADediting_357577(56203880, -), ADediting_357578(56211738, -), ADediting_357579(56211754, -), ADediting_357580(56211864, -), ADediting_357581(56211896, -), ADediting_357582(56213364, -), ADediting_357583(56213393, -), ADediting_357584(56213419, -), ADediting_357585(56213442, -), ADediting_357586(56213455, -), ADediting_357587(56213470, -), ADediting_357588(56213480, -), ADediting_357589(56217384, -), ADediting_357590(56217522, -), ADediting_357591(56218022, -), ADediting_357592(56218037, -), ADediting_357593(56218091, -), ADediting_357594(56218092, -), ADediting_357595(56218118, -), ADediting_357596(56218227, -), ADediting_357597(56218249, -), ADediting_357598(56218977, -), ADediting_357599(56219138, -), ADediting_357600(56219330, -), ADediting_357601(56219356, -), ADediting_357602(56219598, -), ADediting_357603(56219758, -), ADediting_357604(56219770, -), ADediting_357605(56219771, -), ADediting_357606(56219842, -), ADediting_357607(56219917, -), ADediting_357608(56220155, -), ADediting_357609(56220261, -), ADediting_357610(56220347, -), ADediting_357611(56220353, -), ADediting_357612(56220606, -), ADediting_357613(56220622, -), ADediting_357614(56220651, -), ADediting_357615(56220652, -), ADediting_1533286(56203292, -), ADediting_1533287(56203589, -),

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RNA editing positional annotations for RNF41 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_357568chr12_56203280_-UTR3
ADediting_357569chr12_56203300_-UTR3
ADediting_357570chr12_56203324_-UTR3
ADediting_357571chr12_56203513_-UTR3
ADediting_357572chr12_56203802_-UTR3
ADediting_357573chr12_56203817_-UTR3
ADediting_357574chr12_56203834_-UTR3
ADediting_357575chr12_56203844_-UTR3
ADediting_357576chr12_56203870_-UTR3
ADediting_357577chr12_56203880_-UTR3
ADediting_357578chr12_56211738_-intronic
ADediting_357579chr12_56211754_-intronic
ADediting_357580chr12_56211864_-intronic
ADediting_357581chr12_56211896_-intronic
ADediting_357582chr12_56213364_-intronic
ADediting_357583chr12_56213393_-intronic
ADediting_357584chr12_56213419_-intronic
ADediting_357585chr12_56213442_-intronic
ADediting_357586chr12_56213455_-intronic
ADediting_357587chr12_56213470_-intronic
ADediting_357588chr12_56213480_-intronic
ADediting_357589chr12_56217384_-intronic
ADediting_357590chr12_56217522_-intronic
ADediting_357591chr12_56218022_-intronic
ADediting_357592chr12_56218037_-intronic
ADediting_357593chr12_56218091_-intronic
ADediting_357594chr12_56218092_-intronic
ADediting_357595chr12_56218118_-intronic
ADediting_357596chr12_56218227_-intronic
ADediting_357597chr12_56218249_-intronic
ADediting_357598chr12_56218977_-intronic
ADediting_357599chr12_56219138_-intronic
ADediting_357600chr12_56219330_-intronic
ADediting_357601chr12_56219356_-intronic
ADediting_357602chr12_56219598_-intronic
ADediting_357603chr12_56219758_-intronic
ADediting_357604chr12_56219770_-intronic
ADediting_357605chr12_56219771_-intronic
ADediting_357606chr12_56219842_-intronic
ADediting_357607chr12_56219917_-intronic
ADediting_357608chr12_56220155_-intronic
ADediting_357609chr12_56220261_-intronic
ADediting_357610chr12_56220347_-intronic
ADediting_357611chr12_56220353_-intronic
ADediting_357612chr12_56220606_-intronic
ADediting_357613chr12_56220622_-intronic
ADediting_357614chr12_56220651_-intronic
ADediting_357615chr12_56220652_-intronic
ADediting_1533286chr12_56203292_-UTR3
ADediting_1533287chr12_56203589_-UTR3

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_357568chr12_56203280_-SINEAluName=AluSz6
ADediting_357569chr12_56203300_-SINEAluName=AluSz6
ADediting_357570chr12_56203324_-SINEAluName=AluSz6
ADediting_357571chr12_56203513_-SINEAluName=AluY
ADediting_357572chr12_56203802_-SINEAluName=AluY
ADediting_357573chr12_56203817_-SINEAluName=AluY
ADediting_357574chr12_56203834_-SINEAluName=AluY
ADediting_357575chr12_56203844_-SINEAluName=AluY
ADediting_357576chr12_56203870_-SINEAluName=AluY
ADediting_357577chr12_56203880_-SINEAluName=AluY
ADediting_357578chr12_56211738_-SINEAluName=AluYj4
ADediting_357579chr12_56211754_-SINEAluName=AluYj4
ADediting_357580chr12_56211864_-SINEAluName=AluYj4
ADediting_357581chr12_56211896_-SINEAluName=AluYj4
ADediting_357582chr12_56213364_-SINEAluName=AluSc
ADediting_357583chr12_56213393_-SINEAluName=AluSc
ADediting_357584chr12_56213419_-SINEAluName=AluSc
ADediting_357585chr12_56213442_-SINEAluName=AluSc
ADediting_357586chr12_56213455_-SINEAluName=AluSc
ADediting_357587chr12_56213470_-SINEAluName=AluSc
ADediting_357588chr12_56213480_-SINEAluName=AluSc
ADediting_357589chr12_56217384_-SINEAluName=AluSx1
ADediting_357590chr12_56217522_-SINEAluName=AluSx1
ADediting_357591chr12_56218022_-SINEAluName=AluSx1
ADediting_357592chr12_56218037_-SINEAluName=AluSx1
ADediting_357593chr12_56218091_-SINEAluName=AluSx1
ADediting_357594chr12_56218092_-SINEAluName=AluSx1
ADediting_357595chr12_56218118_-SINEAluName=AluSx1
ADediting_357596chr12_56218227_-SINEAluName=AluSx1
ADediting_357597chr12_56218249_-SINEAluName=AluSx1
ADediting_357598chr12_56218977_-SINEAluName=AluSc
ADediting_357599chr12_56219138_-SINEAluName=AluSx
ADediting_357600chr12_56219330_-SINEAluName=AluY
ADediting_357601chr12_56219356_-SINEAluName=AluY
ADediting_357602chr12_56219598_-SINEAluName=AluSx
ADediting_357603chr12_56219758_-SINEAluName=AluJb
ADediting_357604chr12_56219770_-SINEAluName=AluJb
ADediting_357605chr12_56219771_-SINEAluName=AluJb
ADediting_357606chr12_56219842_-SINEAluName=AluJb
ADediting_357607chr12_56219917_-SINEAluName=AluJb
ADediting_357608chr12_56220155_-SINEAluName=AluSx1
ADediting_357609chr12_56220261_-SINEAluName=AluSx3
ADediting_357610chr12_56220347_-SINEAluName=AluSx3
ADediting_357611chr12_56220353_-SINEAluName=AluSx3
ADediting_357612chr12_56220606_-SINEAluName=AluSx1
ADediting_357613chr12_56220622_-SINEAluName=AluSx1
ADediting_357614chr12_56220651_-SINEAluName=AluSx1
ADediting_357615chr12_56220652_-SINEAluName=AluSx1
ADediting_1533286chr12_56203292_-SINEAluName=AluSz6
ADediting_1533287chr12_56203589_-SINEAluName=AluY

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RNA A-to-I editing events in the alternative splicing sites for RNF41

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RNF41

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Soverview
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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for RNF41

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for RNF41

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-145-3pchr1256203287562032937mer-m85620328656203308147-15.3
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-1914-5pchr1256203290562032978mer-1a5620329056203309149-20.8
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6889-3pchr1256203292562032987mer-m85620329156203311150-22.53
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-7152-5pchr1256203289562032957mer-m85620328856203309149-18.96
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-145-3pchr1256203287562032937mer-m85620328656203308147-15.3
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-1914-5pchr1256203290562032978mer-1a5620329056203309149-20.8
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6889-3pchr1256203292562032987mer-m85620329156203311150-22.53
ADediting_1533286chr12_56203292_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-7152-5pchr1256203289562032957mer-m85620328856203309149-18.96
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-3158-3pchr1256203585562035917mer-m85620358456203609149-22.27
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-412-3pchr1256203589562035957mer-m85620358856203610151-19.82
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6754-3pchr1256203589562035957mer-m85620358856203608144-16.46
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-3158-3pchr1256203585562035917mer-m85620358456203609149-22.27
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-412-3pchr1256203589562035957mer-m85620358856203610151-19.82
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6754-3pchr1256203589562035957mer-m85620358856203608144-16.46
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-3155achr1256203276562032827mer-m85620327556203296141-23.87
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-3155bchr1256203276562032827mer-m85620327556203293141-22.98
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-484chr1256203276562032827mer-m85620327556203296149-18.98
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-3155achr1256203276562032827mer-m85620327556203296141-23.87
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-3155bchr1256203276562032827mer-m85620327556203293141-22.98
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-484chr1256203276562032827mer-m85620327556203296149-18.98
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-128-3pchr1256203321562033288mer-1a5620332156203338141-18.62
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-216a-3pchr1256203321562033288mer-1a5620332156203342154-20.32
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-27a-3pchr1256203321562033277mer-m85620332056203337159-27.18
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-27b-3pchr1256203321562033277mer-m85620332056203340155-23.9
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-3681-3pchr1256203321562033288mer-1a5620332156203341156-20.86
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-5693chr1256203324562033307mer-m85620332356203346147-19.5
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-9985chr1256203321562033277mer-m85620332056203338155-19.72
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-128-3pchr1256203321562033288mer-1a5620332156203338141-18.62
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-216a-3pchr1256203321562033288mer-1a5620332156203342154-20.32
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-27a-3pchr1256203321562033277mer-m85620332056203337159-27.18
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-27b-3pchr1256203321562033277mer-m85620332056203340155-23.9
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-3681-3pchr1256203321562033288mer-1a5620332156203341156-20.86
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-5693chr1256203324562033307mer-m85620332356203346147-19.5
ADediting_357570chr12_56203324_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-9985chr1256203321562033277mer-m85620332056203338155-19.72
ADediting_357572chr12_56203802_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4284chr1256203800562038067mer-m85620379956203816148-20.34
ADediting_357572chr12_56203802_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4437chr1256203799562038057mer-m85620379856203818145-18.43
ADediting_357572chr12_56203802_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4284chr1256203800562038067mer-m85620379956203816148-20.34
ADediting_357572chr12_56203802_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4437chr1256203799562038057mer-m85620379856203818145-18.43
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-1207-3pchr1256203834562038407mer-m85620383356203851145-13.53
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-646chr1256203832562038387mer-m85620383156203850148-21.85
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6792-5pchr1256203830562038367mer-m85620382956203852158-25.5
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-1207-3pchr1256203834562038407mer-m85620383356203851145-13.53
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-646chr1256203832562038387mer-m85620383156203850148-21.85
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6792-5pchr1256203830562038367mer-m85620382956203852158-25.5
ADediting_357575chr12_56203844_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-140-3pchr1256203842562038487mer-m85620384156203864149-28.29
ADediting_357575chr12_56203844_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-140-3pchr1256203842562038487mer-m85620384156203864149-28.29
ADediting_357577chr12_56203880_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-153-5pchr1256203880562038867mer-m85620387956203901144-8.17
ADediting_357577chr12_56203880_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-3680-3pchr1256203875562038828mer-1a5620387556203897140-14.25
ADediting_357577chr12_56203880_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-153-5pchr1256203880562038867mer-m85620387956203901144-8.17
ADediting_357577chr12_56203880_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-3680-3pchr1256203875562038828mer-1a5620387556203897140-14.25

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6823-5pchr1256203584562035907mer-m85620358356203603140-14.98
ADediting_1533287chr12_56203589_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6823-5pchr1256203584562035907mer-m85620358356203603140-14.98
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-498-5pchr1256203280562032867mer-m85620327956203301142-10.1
ADediting_357568chr12_56203280_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-498-5pchr1256203280562032867mer-m85620327956203301142-10.1
ADediting_357571chr12_56203513_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-1976chr1256203508562035158mer-1a5620350856203528153-25.04
ADediting_357571chr12_56203513_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6747-3pchr1256203510562035178mer-1a5620351056203532149-23.42
ADediting_357571chr12_56203513_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-1976chr1256203508562035158mer-1a5620350856203528153-25.04
ADediting_357571chr12_56203513_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6747-3pchr1256203510562035178mer-1a5620351056203532149-23.42
ADediting_357573chr12_56203817_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-1976chr1256203812562038198mer-1a5620381256203832153-22.68
ADediting_357573chr12_56203817_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-6747-3pchr1256203814562038218mer-1a5620381456203836149-22.93
ADediting_357573chr12_56203817_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-1976chr1256203812562038198mer-1a5620381256203832153-22.68
ADediting_357573chr12_56203817_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-6747-3pchr1256203814562038218mer-1a5620381456203836149-22.93
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-562chr1256203830562038378mer-1a5620383056203850151-13.72
ADediting_357574chr12_56203834_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-562chr1256203830562038378mer-1a5620383056203850151-13.72
ADediting_357575chr12_56203844_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-8052chr1256203838562038447mer-1a5620383856203858145-20.57
ADediting_357575chr12_56203844_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-8052chr1256203838562038447mer-1a5620383856203858145-20.57
ADediting_357576chr12_56203870_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4735-5pchr1256203869562038757mer-m85620386856203889140-4.28
ADediting_357576chr12_56203870_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4735-5pchr1256203869562038757mer-m85620386856203889140-4.28

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1391023chr8_140732605_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-151a-3pchr1256205234562052407mer-m85620523356205254154-21.42
ADediting_1391023chr8_140732605_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-151a-3pchr1256205234562052407mer-m85620523356205254154-21.42
ADediting_1471004chr9_63819627_+ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4477bchr1256202727562027337mer-m85620272656202746149-17.16
ADediting_1471004chr9_63819627_+ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4477bchr1256202727562027337mer-m85620272656202746149-17.16
ADediting_843620chr2_207754818_+ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4775chr1256205458562054658mer-1a5620545856205478161-10.49
ADediting_843620chr2_207754818_+ENSG00000181852.18ENST00000394013.6RNF41-202hsa-miR-4775chr1256205458562054658mer-1a5620545856205478161-10.49
ADediting_843620chr2_207754818_+ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4775chr1256205458562054658mer-1a5620545856205478161-10.49

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1097295chr3_85385762_+ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-5688chr1256203143562031497mer-m85620314256203163149-9.8
ADediting_1097295chr3_85385762_+ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-5688chr1256203143562031497mer-m85620314256203163149-9.8
ADediting_1337757chr7_5495852_-ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-589-3pchr1256204296562043027mer-m85620429556204318140-10.07
ADediting_1337757chr7_5495852_-ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-589-3pchr1256204296562043027mer-m85620429556204318140-10.07
ADediting_1535951chr14_100874558_+ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-337-3pchr1256205340562053478mer-1a5620534056205362154-13.48
ADediting_1535951chr14_100874558_+ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-337-3pchr1256205340562053478mer-1a5620534056205362154-13.48
ADediting_843620chr2_207754818_+ENSG00000181852.18ENST00000345093.9RNF41-201hsa-miR-4775chr1256202912562029187mer-m85620291156202932140-2.78
ADediting_843620chr2_207754818_+ENSG00000181852.18ENST00000615206.4RNF41-212hsa-miR-4775chr1256202912562029187mer-m85620291156202932140-2.78

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RNF41

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000345093.9protein_codingSoverviewSoverview
ENST00000615206.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_357568ENST00000345093.9chr12_56203280_-4492-1896.90-1891.00-1913.40
ADediting_1533286ENST00000345093.9chr12_56203292_-4480-1893.70-1891.00-1913.40
ADediting_357569ENST00000345093.9chr12_56203300_-4472-1893.00-1891.00-1913.40
ADediting_357570ENST00000345093.9chr12_56203324_-4448-1892.70-1891.00-1913.40
ADediting_357571ENST00000345093.9chr12_56203513_-4259-1894.80-1891.00-1913.40
ADediting_1533287ENST00000345093.9chr12_56203589_-4183-1891.70-1891.00-1913.40
ADediting_357572ENST00000345093.9chr12_56203802_-3970-1897.70-1891.00-1913.40
ADediting_357573ENST00000345093.9chr12_56203817_-3955-1895.70-1891.00-1913.40
ADediting_357574ENST00000345093.9chr12_56203834_-3938-1891.00-1891.00-1913.40
ADediting_357575ENST00000345093.9chr12_56203844_-3928-1894.20-1891.00-1913.40
ADediting_357576ENST00000345093.9chr12_56203870_-3902-1893.20-1891.00-1913.40
ADediting_357577ENST00000345093.9chr12_56203880_-3892-1891.20-1891.00-1913.40
ADediting_357568ENST00000615206.4chr12_56203280_-4440-1729.60-1727.40-1741.50
ADediting_1533286ENST00000615206.4chr12_56203292_-4428-1730.30-1727.40-1741.50
ADediting_357569ENST00000615206.4chr12_56203300_-4420-1728.40-1727.40-1741.50
ADediting_357570ENST00000615206.4chr12_56203324_-4396-1726.40-1727.40-1741.50
ADediting_357571ENST00000615206.4chr12_56203513_-4207-1728.50-1727.40-1741.50
ADediting_1533287ENST00000615206.4chr12_56203589_-4131-1727.70-1727.40-1741.50
ADediting_357572ENST00000615206.4chr12_56203802_-3918-1727.70-1727.40-1741.50
ADediting_357573ENST00000615206.4chr12_56203817_-3903-1726.70-1727.40-1741.50
ADediting_357574ENST00000615206.4chr12_56203834_-3886-1727.40-1727.40-1741.50
ADediting_357575ENST00000615206.4chr12_56203844_-3876-1731.40-1727.40-1741.50
ADediting_357576ENST00000615206.4chr12_56203870_-3850-1729.60-1727.40-1741.50
ADediting_357577ENST00000615206.4chr12_56203880_-3840-1727.60-1727.40-1741.50

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for RNF41

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC1.27417453667886e-980.8741486524458731.32222464729326e-740.8138756075522940.9874787446177550.000894958103646583
AC6.05942531324364e-1130.9341207313338869.29748654250215e-800.8741583282657292.50391178784857e-060.292669660190957
PCC2.59630872622559e-740.9102819225720734.05855910347909e-720.9051035315060030.2045409614597070.0922109395959985
CER2.6327341415052e-480.8742749967079297.38232809565278e-220.6820188823253060.3247966116884630.080941346361639
TCX4.9431920929029e-540.8959642913813376.5537682849101e-300.7635847117564010.651212618038465-0.0372105287928628
FP6.71107531892129e-200.6149829950875731.089097039939e-300.7281944416836770.835996150335329-0.0156257619388327
IFG7.5040878718905e-050.7080413018899440.0004245554375911120.6510184178783570.721063149344012-0.0751541569767813
PG1.21130484702953e-240.6600974777432881.25655881288468e-270.6899927164983480.00967702713268918-0.189258150921304
STG6.74699520197492e-230.8341529087619791.50944806647716e-180.7824479533246120.466112186349459-0.080598885720029

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Relation with AD stages for RNF41

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for RNF41

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for RNF41

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
RNF41C0005586Bipolar Disorder1PSYGENET
RNF41C0041696Unipolar Depression1PSYGENET
RNF41C1269683Major Depressive Disorder1PSYGENET