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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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Gene summary for RASA4 |
 Gene summary |
| Gene information | Gene symbol | RASA4 | Gene ID | 10156 |
| Gene name | RAS p21 protein activator 4 | |
| Synonyms | CAPRI|GAPL | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | ras GTPase-activating protein 4Ca2+-promoted Ras inactivatorcalcium-promoted Ras inactivatorrasGAP-activating-like protein 2 | |
| Modification date | 20200313 | |
| UniProtAcc | O43374, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RASA4 | GO:0034260 | negative regulation of GTPase activity | 12845332 |
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RNA A-to-I events for RASA4 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1290813(102576263, -), ADediting_1290814(102576939, -), ADediting_1290815(102576953, -), ADediting_1290816(102576956, -), ADediting_1290817(102578478, -), ADediting_1290818(102578834, -), ADediting_1290819(102578883, -), ADediting_1290820(102579349, -), ADediting_1290821(102579379, -), ADediting_1290822(102579380, -), ADediting_1290823(102580055, -), ADediting_1290824(102580056, -), ADediting_1290825(102580072, -), ADediting_1290826(102580091, -), ADediting_1290827(102580482, -), ADediting_1290828(102580486, -), ADediting_1290829(102580487, -), ADediting_1290830(102580509, -), ADediting_1290831(102580515, -), ADediting_1290832(102580742, -), ADediting_1290833(102580837, -), ADediting_1290834(102580839, -), ADediting_1290835(102580841, -), ADediting_1290836(102585280, -), ADediting_1290837(102585290, -), ADediting_1290838(102585307, -), ADediting_1290839(102585333, -), ADediting_1290840(102585345, -), ADediting_1290841(102585353, -), ADediting_1290842(102585369, -), ADediting_1290843(102585389, -), ADediting_1290844(102585405, -), ADediting_1290845(102585407, -), ADediting_1290846(102585442, -), ADediting_1290847(102585460, -), ADediting_1290848(102585477, -), ADediting_1290849(102587288, -), ADediting_1290850(102587296, -), ADediting_1290851(102597630, -), ADediting_1290852(102597696, -), ADediting_1290853(102603015, -), ADediting_1290854(102603029, -), ADediting_1290855(102606374, -), ADediting_1585327(102576038, -), ADediting_1585328(102576971, -), ADediting_1585329(102597644, -), ADediting_1585330(102606777, -), ADediting_1585331(102606778, -), ADediting_1585332(102606780, -), |
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RNA editing positional annotations for RASA4 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1290813 | chr7_102576263_- | intronic |
| ADediting_1290814 | chr7_102576939_- | intronic |
| ADediting_1290815 | chr7_102576953_- | intronic |
| ADediting_1290816 | chr7_102576956_- | intronic |
| ADediting_1290817 | chr7_102578478_- | intronic |
| ADediting_1290818 | chr7_102578834_- | intronic |
| ADediting_1290819 | chr7_102578883_- | intronic |
| ADediting_1290820 | chr7_102579349_- | ncRNA_intronic |
| ADediting_1290821 | chr7_102579379_- | ncRNA_intronic |
| ADediting_1290822 | chr7_102579380_- | ncRNA_intronic |
| ADediting_1290823 | chr7_102580055_- | ncRNA_intronic |
| ADediting_1290824 | chr7_102580056_- | ncRNA_intronic |
| ADediting_1290825 | chr7_102580072_- | ncRNA_intronic |
| ADediting_1290826 | chr7_102580091_- | ncRNA_intronic |
| ADediting_1290827 | chr7_102580482_- | ncRNA_intronic |
| ADediting_1290828 | chr7_102580486_- | ncRNA_intronic |
| ADediting_1290829 | chr7_102580487_- | ncRNA_intronic |
| ADediting_1290830 | chr7_102580509_- | ncRNA_intronic |
| ADediting_1290831 | chr7_102580515_- | ncRNA_intronic |
| ADediting_1290832 | chr7_102580742_- | ncRNA_intronic |
| ADediting_1290833 | chr7_102580837_- | ncRNA_intronic |
| ADediting_1290834 | chr7_102580839_- | ncRNA_intronic |
| ADediting_1290835 | chr7_102580841_- | ncRNA_intronic |
| ADediting_1290836 | chr7_102585280_- | ncRNA_intronic |
| ADediting_1290837 | chr7_102585290_- | ncRNA_intronic |
| ADediting_1290838 | chr7_102585307_- | ncRNA_intronic |
| ADediting_1290839 | chr7_102585333_- | ncRNA_intronic |
| ADediting_1290840 | chr7_102585345_- | ncRNA_intronic |
| ADediting_1290841 | chr7_102585353_- | ncRNA_intronic |
| ADediting_1290842 | chr7_102585369_- | ncRNA_intronic |
| ADediting_1290843 | chr7_102585389_- | ncRNA_intronic |
| ADediting_1290844 | chr7_102585405_- | ncRNA_intronic |
| ADediting_1290845 | chr7_102585407_- | ncRNA_intronic |
| ADediting_1290846 | chr7_102585442_- | ncRNA_intronic |
| ADediting_1290847 | chr7_102585460_- | ncRNA_intronic |
| ADediting_1290848 | chr7_102585477_- | ncRNA_intronic |
| ADediting_1290849 | chr7_102587288_- | ncRNA_intronic |
| ADediting_1290850 | chr7_102587296_- | ncRNA_intronic |
| ADediting_1290851 | chr7_102597630_- | ncRNA_intronic |
| ADediting_1290852 | chr7_102597696_- | ncRNA_intronic |
| ADediting_1290853 | chr7_102603015_- | ncRNA_intronic |
| ADediting_1290854 | chr7_102603029_- | ncRNA_intronic |
| ADediting_1290855 | chr7_102606374_- | ncRNA_intronic |
| ADediting_1585327 | chr7_102576038_- | intronic |
| ADediting_1585328 | chr7_102576971_- | intronic |
| ADediting_1585329 | chr7_102597644_- | ncRNA_intronic |
| ADediting_1585330 | chr7_102606777_- | ncRNA_intronic |
| ADediting_1585331 | chr7_102606778_- | ncRNA_intronic |
| ADediting_1585332 | chr7_102606780_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1290813 | chr7_102576263_- | SINE | Alu | Name=AluJo |
| ADediting_1290814 | chr7_102576939_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290815 | chr7_102576953_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290816 | chr7_102576956_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290817 | chr7_102578478_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290818 | chr7_102578834_- | SINE | Alu | Name=AluJo |
| ADediting_1290819 | chr7_102578883_- | SINE | Alu | Name=AluJo |
| ADediting_1290820 | chr7_102579349_- | SINE | Alu | Name=AluSx |
| ADediting_1290821 | chr7_102579379_- | SINE | Alu | Name=AluSx |
| ADediting_1290822 | chr7_102579380_- | SINE | Alu | Name=AluSx |
| ADediting_1290823 | chr7_102580055_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290824 | chr7_102580056_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290825 | chr7_102580072_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290826 | chr7_102580091_- | LINE | L1 | Name=L1MC5a |
| ADediting_1290827 | chr7_102580482_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290828 | chr7_102580486_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290829 | chr7_102580487_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290830 | chr7_102580509_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290831 | chr7_102580515_- | SINE | Alu | Name=FLAM_A |
| ADediting_1290832 | chr7_102580742_- | SINE | Alu | Name=AluSx |
| ADediting_1290833 | chr7_102580837_- | SINE | Alu | Name=AluSx |
| ADediting_1290834 | chr7_102580839_- | SINE | Alu | Name=AluSx |
| ADediting_1290835 | chr7_102580841_- | SINE | Alu | Name=AluSx |
| ADediting_1290836 | chr7_102585280_- | SINE | Alu | Name=AluJr |
| ADediting_1290837 | chr7_102585290_- | SINE | Alu | Name=AluJr |
| ADediting_1290838 | chr7_102585307_- | SINE | Alu | Name=AluJr |
| ADediting_1290839 | chr7_102585333_- | SINE | Alu | Name=AluJr |
| ADediting_1290840 | chr7_102585345_- | SINE | Alu | Name=AluJr |
| ADediting_1290841 | chr7_102585353_- | SINE | Alu | Name=AluJr |
| ADediting_1290842 | chr7_102585369_- | SINE | Alu | Name=AluJr |
| ADediting_1290843 | chr7_102585389_- | SINE | Alu | Name=AluJr |
| ADediting_1290844 | chr7_102585405_- | SINE | Alu | Name=AluJr |
| ADediting_1290845 | chr7_102585407_- | SINE | Alu | Name=AluJr |
| ADediting_1290846 | chr7_102585442_- | SINE | Alu | Name=AluJr |
| ADediting_1290847 | chr7_102585460_- | SINE | Alu | Name=AluJr |
| ADediting_1290848 | chr7_102585477_- | SINE | Alu | Name=AluJr |
| ADediting_1290849 | chr7_102587288_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290850 | chr7_102587296_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290851 | chr7_102597630_- | SINE | Alu | Name=AluSg7 |
| ADediting_1290852 | chr7_102597696_- | SINE | Alu | Name=AluSg7 |
| ADediting_1290853 | chr7_102603015_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290854 | chr7_102603029_- | SINE | Alu | Name=AluSx1 |
| ADediting_1290855 | chr7_102606374_- | SINE | Alu | Name=AluSx |
| ADediting_1585327 | chr7_102576038_- | SINE | Alu | Name=AluSg |
| ADediting_1585328 | chr7_102576971_- | SINE | Alu | Name=AluSx1 |
| ADediting_1585329 | chr7_102597644_- | SINE | Alu | Name=AluSg7 |
| ADediting_1585330 | chr7_102606777_- | SINE | Alu | Name=AluJr |
| ADediting_1585331 | chr7_102606778_- | SINE | Alu | Name=AluJr |
| ADediting_1585332 | chr7_102606780_- | SINE | Alu | Name=AluJr |
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RNA A-to-I editing events in the alternative splicing sites for RASA4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RASA4 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
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| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RASA4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RASA4 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1290823 | chr7_102580055_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-8052 | chr7 | 102580050 | 102580056 | 7mer-1a | 102580050 | 102580068 | 143 | -23.77 |
| ADediting_1290824 | chr7_102580056_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-513a-5p | chr7 | 102580055 | 102580061 | 7mer-m8 | 102580054 | 102580071 | 160 | -21.48 |
| ADediting_1290824 | chr7_102580056_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-638 | chr7 | 102580050 | 102580056 | 7mer-1a | 102580050 | 102580074 | 161 | -34.25 |
| ADediting_1290826 | chr7_102580091_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-103a-3p | chr7 | 102580086 | 102580093 | 8mer-1a | 102580086 | 102580109 | 156 | -14.87 |
| ADediting_1290826 | chr7_102580091_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-107 | chr7 | 102580086 | 102580093 | 8mer-1a | 102580086 | 102580109 | 156 | -14.87 |
| ADediting_1290828 | chr7_102580486_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-3176 | chr7 | 102580486 | 102580492 | 7mer-m8 | 102580485 | 102580504 | 144 | -17.65 |
| ADediting_1290828 | chr7_102580486_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-3922-3p | chr7 | 102580486 | 102580492 | 7mer-m8 | 102580485 | 102580507 | 143 | -18.4 |
| ADediting_1290832 | chr7_102580742_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6089 | chr7 | 102580737 | 102580743 | 7mer-m8 | 102580736 | 102580759 | 160 | -34.6 |
| ADediting_1290833 | chr7_102580837_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-340-3p | chr7 | 102580835 | 102580842 | 8mer-1a | 102580835 | 102580856 | 146 | -18.22 |
| ADediting_1290833 | chr7_102580837_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6827-3p | chr7 | 102580835 | 102580842 | 8mer-1a | 102580835 | 102580855 | 140 | -14.67 |
| ADediting_1290834 | chr7_102580839_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-5001-3p | chr7 | 102580835 | 102580841 | 7mer-m8 | 102580834 | 102580855 | 145 | -15.37 |
| ADediting_1290835 | chr7_102580841_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4433b-5p | chr7 | 102580837 | 102580843 | 7mer-m8 | 102580836 | 102580856 | 140 | -10.81 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1290823 | chr7_102580055_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-10399-5p | chr7 | 102580054 | 102580060 | 7mer-m8 | 102580053 | 102580074 | 152 | -12.02 |
| ADediting_1290823 | chr7_102580055_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-5089-5p | chr7 | 102580050 | 102580056 | 7mer-m8 | 102580049 | 102580068 | 146 | -12.33 |
| ADediting_1290823 | chr7_102580055_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6504-3p | chr7 | 102580054 | 102580060 | 7mer-m8 | 102580053 | 102580074 | 152 | -14.83 |
| ADediting_1290824 | chr7_102580056_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-10399-5p | chr7 | 102580054 | 102580060 | 7mer-m8 | 102580053 | 102580074 | 152 | -12.02 |
| ADediting_1290824 | chr7_102580056_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6504-3p | chr7 | 102580054 | 102580060 | 7mer-m8 | 102580053 | 102580074 | 152 | -14.83 |
| ADediting_1290824 | chr7_102580056_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-7151-3p | chr7 | 102580055 | 102580062 | 8mer-1a | 102580055 | 102580079 | 144 | -19.54 |
| ADediting_1290825 | chr7_102580072_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4252 | chr7 | 102580066 | 102580073 | 8mer-1a | 102580066 | 102580085 | 154 | -21.45 |
| ADediting_1290825 | chr7_102580072_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6529-3p | chr7 | 102580071 | 102580077 | 7mer-m8 | 102580070 | 102580091 | 141 | -12.75 |
| ADediting_1290825 | chr7_102580072_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6889-3p | chr7 | 102580071 | 102580077 | 7mer-m8 | 102580070 | 102580089 | 145 | -18.25 |
| ADediting_1290827 | chr7_102580482_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-3182 | chr7 | 102580478 | 102580484 | 7mer-m8 | 102580477 | 102580493 | 144 | -13.15 |
| ADediting_1290827 | chr7_102580482_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4743-3p | chr7 | 102580479 | 102580485 | 7mer-m8 | 102580478 | 102580496 | 152 | -18.78 |
| ADediting_1290827 | chr7_102580482_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6888-3p | chr7 | 102580479 | 102580486 | 8mer-1a | 102580479 | 102580496 | 147 | -16.36 |
| ADediting_1290829 | chr7_102580487_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6878-3p | chr7 | 102580486 | 102580493 | 8mer-1a | 102580486 | 102580506 | 142 | -13.4 |
| ADediting_1290830 | chr7_102580509_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-520g-5p | chr7 | 102580508 | 102580514 | 7mer-m8 | 102580507 | 102580530 | 153 | -19.25 |
| ADediting_1290830 | chr7_102580509_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6503-3p | chr7 | 102580505 | 102580511 | 7mer-m8 | 102580504 | 102580525 | 149 | -20.95 |
| ADediting_1290832 | chr7_102580742_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4478 | chr7 | 102580738 | 102580744 | 7mer-m8 | 102580737 | 102580753 | 155 | -23.45 |
| ADediting_1290832 | chr7_102580742_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4649-3p | chr7 | 102580741 | 102580747 | 7mer-m8 | 102580740 | 102580760 | 140 | -13.83 |
| ADediting_1290832 | chr7_102580742_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-7160-5p | chr7 | 102580740 | 102580746 | 7mer-m8 | 102580739 | 102580759 | 147 | -20.03 |
| ADediting_1290833 | chr7_102580837_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-3664-5p | chr7 | 102580833 | 102580839 | 7mer-m8 | 102580832 | 102580853 | 153 | -15.28 |
| ADediting_1290833 | chr7_102580837_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4522 | chr7 | 102580832 | 102580838 | 7mer-m8 | 102580831 | 102580851 | 148 | -12.83 |
| ADediting_1290833 | chr7_102580837_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6888-3p | chr7 | 102580835 | 102580841 | 7mer-m8 | 102580834 | 102580854 | 151 | -14.42 |
| ADediting_1290834 | chr7_102580839_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-6888-3p | chr7 | 102580835 | 102580841 | 7mer-m8 | 102580834 | 102580854 | 151 | -14.42 |
| ADediting_1290835 | chr7_102580841_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-371b-5p | chr7 | 102580839 | 102580846 | 8mer-1a | 102580839 | 102580860 | 146 | -7.79 |
| ADediting_1290835 | chr7_102580841_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-373-5p | chr7 | 102580839 | 102580846 | 8mer-1a | 102580839 | 102580860 | 142 | -8.35 |
| ADediting_1290835 | chr7_102580841_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-616-5p | chr7 | 102580839 | 102580846 | 8mer-1a | 102580839 | 102580860 | 140 | -5.71 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4477b | chr7 | 102582069 | 102582076 | 8mer-1a | 102582069 | 102582090 | 142 | -11.37 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4477b | chr7 | 102580415 | 102580422 | 8mer-1a | 102580415 | 102580440 | 152 | -15.26 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4512 | chr7 | 102581252 | 102581258 | 7mer-m8 | 102581251 | 102581272 | 150 | -21.08 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4512 | chr7 | 102582406 | 102582412 | 7mer-1a | 102582406 | 102582427 | 140 | -25.09 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105808.17 | ENST00000449970.6 | RASA4-202 | hsa-miR-4512 | chr7 | 102582406 | 102582412 | 7mer-1a | 102582406 | 102582427 | 140 | -25.09 |
| ADediting_496066 | chr15_66496985_- | ENSG00000105808.17 | ENST00000461209.5 | RASA4-203 | hsa-miR-4512 | chr7 | 102582406 | 102582412 | 7mer-1a | 102582406 | 102582427 | 140 | -25.09 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4775 | chr7 | 102580898 | 102580904 | 7mer-m8 | 102580897 | 102580918 | 140 | -8.46 |
| ADediting_98289 | chr1_32086992_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-5585-3p | chr7 | 102581055 | 102581061 | 7mer-m8 | 102581054 | 102581075 | 147 | -14.28 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1535951 | chr14_100874558_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-337-3p | chr7 | 102580129 | 102580135 | 7mer-m8 | 102580128 | 102580152 | 149 | -9.2 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-381-3p | chr7 | 102579686 | 102579692 | 7mer-1a | 102579686 | 102579707 | 142 | -13.54 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-381-3p | chr7 | 102579686 | 102579692 | 7mer-1a | 102579686 | 102579707 | 142 | -13.54 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000105808.17 | ENST00000262940.11 | RASA4-201 | hsa-miR-4775 | chr7 | 102580410 | 102580417 | 8mer-1a | 102580410 | 102580432 | 145 | -8.22 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RASA4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000262940.11 | protein_coding |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_1290823 | ENST00000262940.11 | chr7_102580055_- | 5196 | -2405.78 | -2399.58 | -2418.98 |
| ADediting_1290824 | ENST00000262940.11 | chr7_102580056_- | 5195 | -2399.38 | -2399.58 | -2418.98 |
| ADediting_1290825 | ENST00000262940.11 | chr7_102580072_- | 5179 | -2403.38 | -2399.58 | -2418.98 |
| ADediting_1290826 | ENST00000262940.11 | chr7_102580091_- | 5160 | -2399.58 | -2399.58 | -2418.98 |
| ADediting_1290827 | ENST00000262940.11 | chr7_102580482_- | 4769 | -2405.78 | -2399.58 | -2418.98 |
| ADediting_1290828 | ENST00000262940.11 | chr7_102580486_- | 4765 | -2399.28 | -2399.58 | -2418.98 |
| ADediting_1290829 | ENST00000262940.11 | chr7_102580487_- | 4764 | -2399.28 | -2399.58 | -2418.98 |
| ADediting_1290830 | ENST00000262940.11 | chr7_102580509_- | 4742 | -2399.18 | -2399.58 | -2418.98 |
| ADediting_1290831 | ENST00000262940.11 | chr7_102580515_- | 4736 | -2401.18 | -2399.58 | -2418.98 |
| ADediting_1290832 | ENST00000262940.11 | chr7_102580742_- | 4509 | -2398.88 | -2399.58 | -2418.98 |
| ADediting_1290833 | ENST00000262940.11 | chr7_102580837_- | 4414 | -2399.78 | -2399.58 | -2418.98 |
| ADediting_1290834 | ENST00000262940.11 | chr7_102580839_- | 4412 | -2399.28 | -2399.58 | -2418.98 |
| ADediting_1290835 | ENST00000262940.11 | chr7_102580841_- | 4410 | -2402.28 | -2399.58 | -2418.98 |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RASA4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| CER | ADediting_1290815 | chr7_102576953_- | 0.0285503312288252 | 0.178835582040245 | 3.79327361758378e-05 | 0.329678747594558 | 0.000201666732092488 | 0.299013199389499 |
| DLPFC | ADediting_1290817 | chr7_102578478_- | 0.32148691626232 | 0.0564913639528917 | 0.528872379487212 | -0.0358996575429888 | 8.85504858925636e-14 | 0.406719965524143 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 5.16276229677794e-12 | 0.378781132458211 | 9.70708593420331e-06 | 0.248300923765892 | 2.49132651630248e-76 | 0.819130919518454 |
| AC | 7.23625271130676e-13 | 0.433340314211036 | 1.14233860336607e-09 | 0.372935863686991 | 5.76754162186612e-14 | 0.451585513651669 |
| PCC | 7.72624458379113e-08 | 0.376849600734541 | 2.02898162371945e-08 | 0.392092936726574 | 2.77521579905929e-05 | 0.298287648140125 |
| CER | 1.42202312409627e-09 | 0.468971528729241 | 1.30652280011796e-12 | 0.537607541153718 | 1.64112365547909e-10 | 0.491838685407094 |
| TCX | 1.42108429416151e-05 | 0.346275851756146 | 0.0405497692902384 | 0.167445215187075 | 0.0020535014213805 | 0.249763792451427 |
| FP | 4.29282844104166e-05 | 0.301596653656943 | 0.00459240287776064 | 0.211521980462686 | 9.50014307415164e-14 | 0.520541207762758 |
| IFG | 0.0600246661631294 | 0.381291840107171 | 0.00131221345391552 | 0.606387240719355 | 0.0131173948868501 | 0.488991901481995 |
| STG | 0.0495985510639064 | 0.21493530210466 | 0.3675747516585 | 0.0995571562426311 | 1.24260528419426e-09 | 0.603380729953042 |
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Relation with AD stages for RASA4 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 4.40570773199777e-09 | 0.527687258865365 |
| TCX | 6.58844504812837e-07 | 0.461009628199126 |
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RelatedDrugs for RASA4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASA4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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