|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for COX5BP6 |
 Gene summary |
| Gene information | Gene symbol | COX5BP6 | Gene ID | 101234262 |
| Gene name | cytochrome c oxidase subunit 5B pseudogene 6 | |
| Synonyms | COX5BL6 | |
| Cytomap | 13q32.3 | |
| Type of gene | pseudo | |
| Description | cytochrome c oxidase subunit Vb pseudogene 6cytochrome c oxidase subunit Vb-like 6 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for COX5BP6 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_380865(100623938, -), ADediting_380866(100623971, -), ADediting_380867(100624054, -), ADediting_380868(100624064, -), ADediting_380869(100624070, -), ADediting_380870(100624082, -), ADediting_380871(100624092, -), ADediting_380872(100624123, -), ADediting_380873(100624133, -), ADediting_380874(100624137, -), ADediting_380875(100624145, -), ADediting_380876(100624159, -), ADediting_380877(100624162, -), ADediting_380878(100624168, -), ADediting_380879(100624204, -), ADediting_380880(100624226, -), ADediting_380881(100624263, -), ADediting_380882(100624315, -), ADediting_380883(100624320, -), ADediting_380884(100624328, -), ADediting_380885(100624340, -), ADediting_1534574(100624084, -), ADediting_1534575(100624338, -), ADediting_1615709(100624202, -), ADediting_1615710(100624244, -), |
Top |
RNA editing positional annotations for COX5BP6 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_380865 | chr13_100623938_- | ncRNA_exonic |
| ADediting_380866 | chr13_100623971_- | ncRNA_exonic |
| ADediting_380867 | chr13_100624054_- | ncRNA_intronic |
| ADediting_380868 | chr13_100624064_- | ncRNA_intronic |
| ADediting_380869 | chr13_100624070_- | ncRNA_intronic |
| ADediting_380870 | chr13_100624082_- | ncRNA_intronic |
| ADediting_380871 | chr13_100624092_- | ncRNA_intronic |
| ADediting_380872 | chr13_100624123_- | ncRNA_intronic |
| ADediting_380873 | chr13_100624133_- | ncRNA_intronic |
| ADediting_380874 | chr13_100624137_- | ncRNA_intronic |
| ADediting_380875 | chr13_100624145_- | ncRNA_intronic |
| ADediting_380876 | chr13_100624159_- | ncRNA_intronic |
| ADediting_380877 | chr13_100624162_- | ncRNA_intronic |
| ADediting_380878 | chr13_100624168_- | ncRNA_intronic |
| ADediting_380879 | chr13_100624204_- | ncRNA_intronic |
| ADediting_380880 | chr13_100624226_- | ncRNA_intronic |
| ADediting_380881 | chr13_100624263_- | ncRNA_intronic |
| ADediting_380882 | chr13_100624315_- | ncRNA_intronic |
| ADediting_380883 | chr13_100624320_- | ncRNA_intronic |
| ADediting_380884 | chr13_100624328_- | ncRNA_intronic |
| ADediting_380885 | chr13_100624340_- | ncRNA_intronic |
| ADediting_1534574 | chr13_100624084_- | ncRNA_intronic |
| ADediting_1534575 | chr13_100624338_- | ncRNA_intronic |
| ADediting_1615709 | chr13_100624202_- | ncRNA_intronic |
| ADediting_1615710 | chr13_100624244_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_380867 | chr13_100624054_- | SINE | Alu | Name=AluY |
| ADediting_380868 | chr13_100624064_- | SINE | Alu | Name=AluY |
| ADediting_380869 | chr13_100624070_- | SINE | Alu | Name=AluY |
| ADediting_380870 | chr13_100624082_- | SINE | Alu | Name=AluY |
| ADediting_380871 | chr13_100624092_- | SINE | Alu | Name=AluY |
| ADediting_380872 | chr13_100624123_- | SINE | Alu | Name=AluY |
| ADediting_380873 | chr13_100624133_- | SINE | Alu | Name=AluY |
| ADediting_380874 | chr13_100624137_- | SINE | Alu | Name=AluY |
| ADediting_380875 | chr13_100624145_- | SINE | Alu | Name=AluY |
| ADediting_380876 | chr13_100624159_- | SINE | Alu | Name=AluY |
| ADediting_380877 | chr13_100624162_- | SINE | Alu | Name=AluY |
| ADediting_380878 | chr13_100624168_- | SINE | Alu | Name=AluY |
| ADediting_380879 | chr13_100624204_- | SINE | Alu | Name=AluY |
| ADediting_380880 | chr13_100624226_- | SINE | Alu | Name=AluY |
| ADediting_380881 | chr13_100624263_- | SINE | Alu | Name=AluY |
| ADediting_380882 | chr13_100624315_- | SINE | Alu | Name=AluY |
| ADediting_380883 | chr13_100624320_- | SINE | Alu | Name=AluY |
| ADediting_380884 | chr13_100624328_- | SINE | Alu | Name=AluY |
| ADediting_380885 | chr13_100624340_- | SINE | Alu | Name=AluY |
| ADediting_1534574 | chr13_100624084_- | SINE | Alu | Name=AluY |
| ADediting_1534575 | chr13_100624338_- | SINE | Alu | Name=AluY |
| ADediting_1615709 | chr13_100624202_- | SINE | Alu | Name=AluY |
| ADediting_1615710 | chr13_100624244_- | SINE | Alu | Name=AluY |
Top |
RNA A-to-I editing events in the alternative splicing sites for COX5BP6 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for COX5BP6 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for COX5BP6 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for COX5BP6 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for COX5BP6 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for COX5BP6 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | 0.12792499962229 | 0.124855750363934 | 0.0031931311491874 | -0.239239823410881 | 1.36462799012406e-11 | 0.516240380879083 |
| PG | 2.09841236621205e-09 | 0.421420376469158 | 0.000157325815071548 | 0.273642050811038 | 0.0758343854420407 | 0.130499995910722 |
| STG | 0.000602684981595465 | 0.366656579188055 | 0.0912916554637316 | 0.185420831524818 | 0.00147204578408831 | 0.341599288321068 |
Top |
Relation with AD stages for COX5BP6 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
Top |
RelatedDrugs for COX5BP6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COX5BP6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|