|
||||||
|
 | |
| |
| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
| |
| |
| The effects of the RNA editing to the stability of the RNA structures |
| |
| |
| |
|
Gene summary for FNBP1P1 |
 Gene summary |
| Gene information | Gene symbol | FNBP1P1 | Gene ID | 100533642 |
| Gene name | formin binding protein 1 pseudogene 1 | |
| Synonyms | - | |
| Cytomap | 2p13.1 | |
| Type of gene | pseudo | |
| Description | - | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
RNA A-to-I events for FNBP1P1 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA editing frequencies across three data sets. |
 |
| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
 |
| RNA A-to-I editing events in AD. |
| ADediting_900032(74121723, +), ADediting_900033(74121733, +), ADediting_900034(74121739, +), ADediting_900035(74121748, +), ADediting_900036(74121753, +), ADediting_900037(74121769, +), ADediting_900038(74121778, +), ADediting_900039(74121821, +), ADediting_900040(74121822, +), ADediting_900041(74121827, +), ADediting_900042(74121871, +), ADediting_900043(74121877, +), ADediting_900044(74121878, +), ADediting_900045(74121883, +), ADediting_900046(74121887, +), ADediting_900047(74121900, +), ADediting_900048(74121942, +), ADediting_900049(74121943, +), ADediting_900050(74121953, +), ADediting_900051(74122000, +), ADediting_900052(74122757, +), ADediting_900053(74122832, +), ADediting_900054(74122838, +), ADediting_900055(74122859, +), ADediting_900056(74122886, +), ADediting_900057(74122891, +), ADediting_900058(74122894, +), ADediting_900059(74122928, +), ADediting_900060(74122937, +), ADediting_900061(74122968, +), ADediting_1564524(74121820, +), ADediting_1564525(74121855, +), |
Top |
RNA editing positional annotations for FNBP1P1 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_900032 | chr2_74121723_+ | ncRNA_exonic |
| ADediting_900033 | chr2_74121733_+ | ncRNA_exonic |
| ADediting_900034 | chr2_74121739_+ | ncRNA_exonic |
| ADediting_900035 | chr2_74121748_+ | ncRNA_exonic |
| ADediting_900036 | chr2_74121753_+ | ncRNA_exonic |
| ADediting_900037 | chr2_74121769_+ | ncRNA_exonic |
| ADediting_900038 | chr2_74121778_+ | ncRNA_exonic |
| ADediting_900039 | chr2_74121821_+ | ncRNA_exonic |
| ADediting_900040 | chr2_74121822_+ | ncRNA_exonic |
| ADediting_900041 | chr2_74121827_+ | ncRNA_exonic |
| ADediting_900042 | chr2_74121871_+ | ncRNA_exonic |
| ADediting_900043 | chr2_74121877_+ | ncRNA_exonic |
| ADediting_900044 | chr2_74121878_+ | ncRNA_exonic |
| ADediting_900045 | chr2_74121883_+ | ncRNA_exonic |
| ADediting_900046 | chr2_74121887_+ | ncRNA_exonic |
| ADediting_900047 | chr2_74121900_+ | ncRNA_exonic |
| ADediting_900048 | chr2_74121942_+ | ncRNA_exonic |
| ADediting_900049 | chr2_74121943_+ | ncRNA_exonic |
| ADediting_900050 | chr2_74121953_+ | ncRNA_exonic |
| ADediting_900051 | chr2_74122000_+ | ncRNA_exonic |
| ADediting_900052 | chr2_74122757_+ | ncRNA_intronic |
| ADediting_900053 | chr2_74122832_+ | ncRNA_intronic |
| ADediting_900054 | chr2_74122838_+ | ncRNA_intronic |
| ADediting_900055 | chr2_74122859_+ | ncRNA_intronic |
| ADediting_900056 | chr2_74122886_+ | ncRNA_intronic |
| ADediting_900057 | chr2_74122891_+ | ncRNA_intronic |
| ADediting_900058 | chr2_74122894_+ | ncRNA_intronic |
| ADediting_900059 | chr2_74122928_+ | ncRNA_intronic |
| ADediting_900060 | chr2_74122937_+ | ncRNA_intronic |
| ADediting_900061 | chr2_74122968_+ | ncRNA_intronic |
| ADediting_1564524 | chr2_74121820_+ | ncRNA_exonic |
| ADediting_1564525 | chr2_74121855_+ | ncRNA_exonic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_900032 | chr2_74121723_+ | SINE | Alu | Name=AluSz |
| ADediting_900033 | chr2_74121733_+ | SINE | Alu | Name=AluSz |
| ADediting_900034 | chr2_74121739_+ | SINE | Alu | Name=AluSz |
| ADediting_900035 | chr2_74121748_+ | SINE | Alu | Name=AluSz |
| ADediting_900036 | chr2_74121753_+ | SINE | Alu | Name=AluSz |
| ADediting_900037 | chr2_74121769_+ | SINE | Alu | Name=AluSz |
| ADediting_900038 | chr2_74121778_+ | SINE | Alu | Name=AluSz |
| ADediting_900039 | chr2_74121821_+ | SINE | Alu | Name=AluSz |
| ADediting_900040 | chr2_74121822_+ | SINE | Alu | Name=AluSz |
| ADediting_900041 | chr2_74121827_+ | SINE | Alu | Name=AluSz |
| ADediting_900042 | chr2_74121871_+ | SINE | Alu | Name=AluSz |
| ADediting_900043 | chr2_74121877_+ | SINE | Alu | Name=AluSz |
| ADediting_900044 | chr2_74121878_+ | SINE | Alu | Name=AluSz |
| ADediting_900045 | chr2_74121883_+ | SINE | Alu | Name=AluSz |
| ADediting_900046 | chr2_74121887_+ | SINE | Alu | Name=AluSz |
| ADediting_900047 | chr2_74121900_+ | SINE | Alu | Name=AluSz |
| ADediting_900048 | chr2_74121942_+ | SINE | Alu | Name=AluSz |
| ADediting_900049 | chr2_74121943_+ | SINE | Alu | Name=AluSz |
| ADediting_900050 | chr2_74121953_+ | SINE | Alu | Name=AluSz |
| ADediting_900051 | chr2_74122000_+ | SINE | Alu | Name=AluSz |
| ADediting_900052 | chr2_74122757_+ | SINE | Alu | Name=AluSc8 |
| ADediting_900053 | chr2_74122832_+ | SINE | Alu | Name=AluSc8 |
| ADediting_900054 | chr2_74122838_+ | SINE | Alu | Name=AluSc8 |
| ADediting_900055 | chr2_74122859_+ | SINE | Alu | Name=AluJb |
| ADediting_900056 | chr2_74122886_+ | SINE | Alu | Name=AluJb |
| ADediting_900057 | chr2_74122891_+ | SINE | Alu | Name=AluJb |
| ADediting_900058 | chr2_74122894_+ | SINE | Alu | Name=AluJb |
| ADediting_900059 | chr2_74122928_+ | SINE | Alu | Name=AluJb |
| ADediting_900060 | chr2_74122937_+ | SINE | Alu | Name=AluJb |
| ADediting_900061 | chr2_74122968_+ | SINE | Alu | Name=AluJb |
| ADediting_1564524 | chr2_74121820_+ | SINE | Alu | Name=AluSz |
| ADediting_1564525 | chr2_74121855_+ | SINE | Alu | Name=AluSz |
Top |
RNA A-to-I editing events in the alternative splicing sites for FNBP1P1 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for FNBP1P1 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
 | |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
Top |
Protein coding region RNA A-to-I editings for FNBP1P1 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for FNBP1P1 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
Top |
The effects of the RNA editing to the stability of the RNA structures for FNBP1P1 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for FNBP1P1 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| TCX | ADediting_900032 | chr2_74121723_+ | 0.0589714214997106 | 0.15455286724478 | 0.141666326935325 | -0.120563901336518 | 1.79255283948779e-07 | 0.410665644920942 |
| TCX | ADediting_900033 | chr2_74121733_+ | 0.645009663122599 | 0.0379201596865891 | 0.0870854379057016 | -0.140182664067686 | 6.47689386296864e-05 | 0.320216008482152 |
| TCX | ADediting_900037 | chr2_74121769_+ | 0.313767309215596 | 0.0828009971584325 | 0.467087413802009 | -0.0598250203947569 | 0.000144049117002378 | 0.30546326346235 |
| TCX | ADediting_900042 | chr2_74121871_+ | 0.29273369102847 | 0.0864694982852165 | 0.179182779076446 | -0.110265654084588 | 3.45603235733548e-08 | 0.431764795112884 |
| TCX | ADediting_900043 | chr2_74121877_+ | 0.496632011965018 | 0.055929729725735 | 0.0589612045063672 | -0.154559026047376 | 1.61760533093232e-08 | 0.441030577381205 |
| TCX | ADediting_900044 | chr2_74121878_+ | 0.919371010030649 | 0.00833465310863926 | 0.00505634398652259 | -0.227786876286801 | 6.11429977084005e-08 | 0.424614438241517 |
| TCX | ADediting_900048 | chr2_74121942_+ | 0.213733428899979 | 0.102108926664461 | 0.103070705732149 | -0.133621070253924 | 2.5123535473043e-14 | 0.570500226007598 |
| TCX | ADediting_900049 | chr2_74121943_+ | 0.626823045472652 | 0.0400171859915711 | 0.236793474561058 | -0.0971789101310702 | 8.0021564385037e-05 | 0.316387419523742 |
| TCX | ADediting_900050 | chr2_74121953_+ | 0.051017906676694 | 0.159637509313531 | 0.713760700877346 | -0.0301956856158532 | 3.8214128047661e-08 | 0.430517150572289 |
| DLPFC | ADediting_900058 | chr2_74122894_+ | 0.0256512648017798 | 0.126738418237655 | 0.863488197235804 | -0.00980465680645147 | 4.03612785430891e-11 | 0.363568702124288 |
| TCX | ADediting_900058 | chr2_74122894_+ | 0.0798733333840344 | 0.14346241403464 | 0.145766558016269 | -0.119345011725685 | 2.98082933331285e-08 | 0.433592041443496 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 8.46888955703074e-11 | 0.357884118987409 | 1.74262877549896e-07 | 0.29146320604948 | 1.05931244858273e-20 | 0.496521584553949 |
| AC | 4.36011215981529e-06 | 0.285861847203834 | 0.000916037045777435 | 0.208404162155597 | 3.66502637911855e-09 | 0.362138454540234 |
| PCC | 3.41320602985535e-07 | 0.358942438175388 | 7.1305333459214e-06 | 0.318459412529308 | 1.66171835876821e-07 | 0.367754407724029 |
| CER | 9.90681418239197e-11 | 0.496949288850064 | 0.00118684817050217 | 0.262254912004283 | 0.00430639209242718 | 0.231848207537533 |
| TCX | 2.45991286586482e-06 | 0.373776474321596 | 0.306735800173011 | -0.0840088764427282 | 9.39049767341326e-22 | 0.680750320365452 |
| FP | 3.2213420634482e-13 | 0.510811962946033 | 0.0024252312990873 | 0.225941942013642 | 1.80828635776022e-08 | 0.406447613861841 |
| PG | 4.83655711074234e-30 | 0.711794182153418 | 5.16723301756004e-14 | 0.515419136054937 | 0.0498625026953338 | 0.144018216024348 |
| STG | 1.49304180778707e-07 | 0.535917795639998 | 0.00778699002545764 | 0.288479164851404 | 1.21069629057844e-06 | 0.501011773042564 |
Top |
Relation with AD stages for FNBP1P1 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 0.000402432386251334 | 0.337545581185549 |
Top |
RelatedDrugs for FNBP1P1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FNBP1P1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| FNBP1P1 | C0003165 | Anthracosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|