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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited versus non-edited samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for ZNF816-ZNF321P

check button Gene summary
Gene informationGene symbol

ZNF816-ZNF321P

Gene ID

100529240

Gene nameZNF816-ZNF321P readthrough
SynonymsZNF816-ZNF321
Cytomap

19q13.41

Type of geneprotein-coding
DescriptionZNF816-ZNF321 proteinZNF816-ZNF321 read-through transcriptZNF816-ZNF321 readthrough
Modification date20200313
UniProtAcc

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for ZNF816-ZNF321P

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_780502(52945763, -), ADediting_780503(52945888, -), ADediting_780504(52947075, -), ADediting_780505(52947088, -), ADediting_780506(52947092, -), ADediting_780507(52947118, -), ADediting_780508(52947128, -), ADediting_780509(52947142, -), ADediting_780510(52947724, -), ADediting_780511(52947749, -), ADediting_780512(52947773, -), ADediting_780513(52947788, -), ADediting_780514(52947805, -), ADediting_780515(52947815, -), ADediting_780516(52947841, -), ADediting_780517(52947851, -), ADediting_780518(52947853, -), ADediting_780519(52947871, -), ADediting_780520(52947905, -), ADediting_780521(52948366, -), ADediting_780522(52948367, -), ADediting_780523(52948396, -), ADediting_780524(52948401, -), ADediting_780525(52948409, -), ADediting_780526(52948410, -), ADediting_780527(52948427, -), ADediting_780528(52948693, -), ADediting_780529(52948694, -), ADediting_780530(52948708, -), ADediting_780531(52948721, -), ADediting_780532(52948727, -), ADediting_780533(52948775, -), ADediting_780534(52948790, -), ADediting_780535(52948816, -), ADediting_780536(52948826, -), ADediting_780537(52948851, -), ADediting_780538(52948855, -), ADediting_780539(52948956, -), ADediting_780540(52948961, -), ADediting_780541(52949013, -), ADediting_780542(52949048, -), ADediting_780543(52949049, -), ADediting_780544(52949052, -), ADediting_780545(52949053, -), ADediting_780546(52949066, -), ADediting_780547(52949078, -), ADediting_780548(52949083, -), ADediting_780549(52949096, -), ADediting_780550(52949104, -), ADediting_780551(52949148, -), ADediting_780552(52951776, -), ADediting_780553(52951786, -), ADediting_780554(52951812, -), ADediting_780555(52951815, -), ADediting_780556(52952134, -), ADediting_780557(52952151, -), ADediting_780558(52952152, -), ADediting_780559(52952176, -), ADediting_780560(52952287, -), ADediting_780561(52952293, -), ADediting_1558568(52945903, -), ADediting_1558569(52945907, -), ADediting_1558570(52945940, -), ADediting_1558571(52947049, -), ADediting_1558572(52947085, -), ADediting_1558573(52947101, -), ADediting_1558574(52947136, -), ADediting_1558575(52947203, -), ADediting_1558576(52948395, -), ADediting_1558577(52948681, -), ADediting_1558578(52948712, -), ADediting_1558579(52948772, -), ADediting_1558580(52948799, -), ADediting_1558581(52948830, -), ADediting_1558582(52948894, -), ADediting_1558583(52949023, -), ADediting_1558584(52949091, -), ADediting_1558585(52949093, -), ADediting_1558586(52949274, -), ADediting_1558587(52952098, -), ADediting_1558588(52952139, -), ADediting_1558589(52952241, -), ADediting_1558590(52952283, -), ADediting_1558591(52952284, -),

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RNA editing positional annotations for ZNF816-ZNF321P using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_780502chr19_52945763_-intronic
ADediting_780503chr19_52945888_-intronic
ADediting_780504chr19_52947075_-intronic
ADediting_780505chr19_52947088_-intronic
ADediting_780506chr19_52947092_-intronic
ADediting_780507chr19_52947118_-intronic
ADediting_780508chr19_52947128_-intronic
ADediting_780509chr19_52947142_-intronic
ADediting_780510chr19_52947724_-intronic
ADediting_780511chr19_52947749_-intronic
ADediting_780512chr19_52947773_-intronic
ADediting_780513chr19_52947788_-intronic
ADediting_780514chr19_52947805_-intronic
ADediting_780515chr19_52947815_-intronic
ADediting_780516chr19_52947841_-intronic
ADediting_780517chr19_52947851_-intronic
ADediting_780518chr19_52947853_-intronic
ADediting_780519chr19_52947871_-intronic
ADediting_780520chr19_52947905_-intronic
ADediting_780521chr19_52948366_-intronic
ADediting_780522chr19_52948367_-intronic
ADediting_780523chr19_52948396_-intronic
ADediting_780524chr19_52948401_-intronic
ADediting_780525chr19_52948409_-intronic
ADediting_780526chr19_52948410_-intronic
ADediting_780527chr19_52948427_-intronic
ADediting_780528chr19_52948693_-intronic
ADediting_780529chr19_52948694_-intronic
ADediting_780530chr19_52948708_-intronic
ADediting_780531chr19_52948721_-intronic
ADediting_780532chr19_52948727_-intronic
ADediting_780533chr19_52948775_-intronic
ADediting_780534chr19_52948790_-intronic
ADediting_780535chr19_52948816_-intronic
ADediting_780536chr19_52948826_-intronic
ADediting_780537chr19_52948851_-intronic
ADediting_780538chr19_52948855_-intronic
ADediting_780539chr19_52948956_-intronic
ADediting_780540chr19_52948961_-intronic
ADediting_780541chr19_52949013_-intronic
ADediting_780542chr19_52949048_-intronic
ADediting_780543chr19_52949049_-intronic
ADediting_780544chr19_52949052_-intronic
ADediting_780545chr19_52949053_-intronic
ADediting_780546chr19_52949066_-intronic
ADediting_780547chr19_52949078_-intronic
ADediting_780548chr19_52949083_-intronic
ADediting_780549chr19_52949096_-intronic
ADediting_780550chr19_52949104_-intronic
ADediting_780551chr19_52949148_-intronic
ADediting_780552chr19_52951776_-UTR3
ADediting_780553chr19_52951786_-UTR3
ADediting_780554chr19_52951812_-UTR3
ADediting_780555chr19_52951815_-UTR3
ADediting_780556chr19_52952134_-intronic
ADediting_780557chr19_52952151_-intronic
ADediting_780558chr19_52952152_-intronic
ADediting_780559chr19_52952176_-intronic
ADediting_780560chr19_52952287_-intronic
ADediting_780561chr19_52952293_-intronic
ADediting_1558568chr19_52945903_-intronic
ADediting_1558569chr19_52945907_-intronic
ADediting_1558570chr19_52945940_-intronic
ADediting_1558571chr19_52947049_-intronic
ADediting_1558572chr19_52947085_-intronic
ADediting_1558573chr19_52947101_-intronic
ADediting_1558574chr19_52947136_-intronic
ADediting_1558575chr19_52947203_-intronic
ADediting_1558576chr19_52948395_-intronic
ADediting_1558577chr19_52948681_-intronic
ADediting_1558578chr19_52948712_-intronic
ADediting_1558579chr19_52948772_-intronic
ADediting_1558580chr19_52948799_-intronic
ADediting_1558581chr19_52948830_-intronic
ADediting_1558582chr19_52948894_-intronic
ADediting_1558583chr19_52949023_-intronic
ADediting_1558584chr19_52949091_-intronic
ADediting_1558585chr19_52949093_-intronic
ADediting_1558586chr19_52949274_-intronic
ADediting_1558587chr19_52952098_-intronic
ADediting_1558588chr19_52952139_-intronic
ADediting_1558589chr19_52952241_-intronic
ADediting_1558590chr19_52952283_-intronic
ADediting_1558591chr19_52952284_-intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_780502chr19_52945763_-SINEAluName=AluJo
ADediting_780503chr19_52945888_-SINEAluName=AluJo
ADediting_780504chr19_52947075_-SINEAluName=AluSx1
ADediting_780505chr19_52947088_-SINEAluName=AluSx1
ADediting_780506chr19_52947092_-SINEAluName=AluSx1
ADediting_780507chr19_52947118_-SINEAluName=AluSx1
ADediting_780508chr19_52947128_-SINEAluName=AluSx1
ADediting_780509chr19_52947142_-SINEAluName=AluSx1
ADediting_780510chr19_52947724_-SINEAluName=AluY
ADediting_780511chr19_52947749_-SINEAluName=AluY
ADediting_780512chr19_52947773_-SINEAluName=AluY
ADediting_780513chr19_52947788_-SINEAluName=AluY
ADediting_780514chr19_52947805_-SINEAluName=AluY
ADediting_780515chr19_52947815_-SINEAluName=AluY
ADediting_780516chr19_52947841_-SINEAluName=AluY
ADediting_780517chr19_52947851_-SINEAluName=AluY
ADediting_780518chr19_52947853_-SINEAluName=AluY
ADediting_780519chr19_52947871_-SINEAluName=AluY
ADediting_780520chr19_52947905_-SINEAluName=AluY
ADediting_780521chr19_52948366_-SINEAluName=AluSq2
ADediting_780522chr19_52948367_-SINEAluName=AluSq2
ADediting_780523chr19_52948396_-SINEAluName=AluSq2
ADediting_780524chr19_52948401_-SINEAluName=AluSq2
ADediting_780525chr19_52948409_-SINEAluName=AluSq2
ADediting_780526chr19_52948410_-SINEAluName=AluSq2
ADediting_780527chr19_52948427_-SINEAluName=AluSq2
ADediting_780528chr19_52948693_-SINEAluName=AluSx1
ADediting_780529chr19_52948694_-SINEAluName=AluSx1
ADediting_780530chr19_52948708_-SINEAluName=AluSx1
ADediting_780531chr19_52948721_-SINEAluName=AluSx1
ADediting_780532chr19_52948727_-SINEAluName=AluSx1
ADediting_780533chr19_52948775_-SINEAluName=AluSx1
ADediting_780534chr19_52948790_-SINEAluName=AluSx1
ADediting_780535chr19_52948816_-SINEAluName=AluSx1
ADediting_780536chr19_52948826_-SINEAluName=AluSx1
ADediting_780537chr19_52948851_-SINEAluName=AluSx1
ADediting_780538chr19_52948855_-SINEAluName=AluSx1
ADediting_780539chr19_52948956_-SINEAluName=AluSx1
ADediting_780540chr19_52948961_-SINEAluName=AluSx1
ADediting_780541chr19_52949013_-SINEAluName=AluSq2
ADediting_780542chr19_52949048_-SINEAluName=AluSq2
ADediting_780543chr19_52949049_-SINEAluName=AluSq2
ADediting_780544chr19_52949052_-SINEAluName=AluSq2
ADediting_780545chr19_52949053_-SINEAluName=AluSq2
ADediting_780546chr19_52949066_-SINEAluName=AluSq2
ADediting_780547chr19_52949078_-SINEAluName=AluSq2
ADediting_780548chr19_52949083_-SINEAluName=AluSq2
ADediting_780549chr19_52949096_-SINEAluName=AluSq2
ADediting_780550chr19_52949104_-SINEAluName=AluSq2
ADediting_780551chr19_52949148_-SINEAluName=AluSq2
ADediting_780552chr19_52951776_-SINEAluName=AluSq2
ADediting_780553chr19_52951786_-SINEAluName=AluSq2
ADediting_780554chr19_52951812_-SINEAluName=AluSq2
ADediting_780555chr19_52951815_-SINEAluName=AluSq2
ADediting_780556chr19_52952134_-SINEAluName=AluSz6
ADediting_780557chr19_52952151_-SINEAluName=AluSz6
ADediting_780558chr19_52952152_-SINEAluName=AluSz6
ADediting_780559chr19_52952176_-SINEAluName=AluSz6
ADediting_780560chr19_52952287_-SINEAluName=AluSz6
ADediting_780561chr19_52952293_-SINEAluName=AluSz6
ADediting_1558568chr19_52945903_-SINEAluName=AluJo
ADediting_1558569chr19_52945907_-SINEAluName=AluJo
ADediting_1558570chr19_52945940_-SINEAluName=AluJo
ADediting_1558571chr19_52947049_-SINEAluName=AluSx1
ADediting_1558572chr19_52947085_-SINEAluName=AluSx1
ADediting_1558573chr19_52947101_-SINEAluName=AluSx1
ADediting_1558574chr19_52947136_-SINEAluName=AluSx1
ADediting_1558575chr19_52947203_-SINEAluName=AluSx1
ADediting_1558576chr19_52948395_-SINEAluName=AluSq2
ADediting_1558577chr19_52948681_-SINEAluName=AluSx1
ADediting_1558578chr19_52948712_-SINEAluName=AluSx1
ADediting_1558579chr19_52948772_-SINEAluName=AluSx1
ADediting_1558580chr19_52948799_-SINEAluName=AluSx1
ADediting_1558581chr19_52948830_-SINEAluName=AluSx1
ADediting_1558582chr19_52948894_-SINEAluName=AluSx1
ADediting_1558583chr19_52949023_-SINEAluName=AluSq2
ADediting_1558584chr19_52949091_-SINEAluName=AluSq2
ADediting_1558585chr19_52949093_-SINEAluName=AluSq2
ADediting_1558586chr19_52949274_-SINEAluName=AluSz
ADediting_1558587chr19_52952098_-SINEAluName=AluSz6
ADediting_1558588chr19_52952139_-SINEAluName=AluSz6
ADediting_1558589chr19_52952241_-SINEAluName=AluSz6
ADediting_1558590chr19_52952283_-SINEAluName=AluSz6
ADediting_1558591chr19_52952284_-SINEAluName=AluSz6

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RNA A-to-I editing events in the alternative splicing sites for ZNF816-ZNF321P

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF816-ZNF321P

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for ZNF816-ZNF321P

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for ZNF816-ZNF321P


check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1535953chr14_101045971_+ENSG00000221874.4ENST00000391777.3ZNF816-ZNF321P-201hsa-miR-381-3pchr1952928778529287847mer-m85292877752928799151-18.85
ADediting_1535954chr14_101045974_+ENSG00000221874.4ENST00000391777.3ZNF816-ZNF321P-201hsa-miR-381-3pchr1952928778529287847mer-m85292877752928799151-18.85

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF816-ZNF321P

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ZNF816-ZNF321P

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CERADediting_780504chr19_52947075_-0.005002245898864810.2280611225318010.0001254519551775620.308070502902640.2769855253300680.0893323619303686
CERADediting_780505chr19_52947088_-5.94294375471528e-050.3217590299475827.08533319776163e-060.3574956134466910.01671331072876950.195134241360757
CERADediting_780507chr19_52947118_-1.69313133820548e-060.3793201802650661.60336174565848e-080.4411369073246090.1117843595091060.130377061821668
CERADediting_780524chr19_52948401_-0.02316132302408240.1853480328288037.32340956210809e-050.3179984170244020.03694651845989220.17052688248491
CERADediting_780525chr19_52948409_-0.004191136323197120.2325278650003060.000152587996441120.3043698642175650.005187313613519760.227133653208935
CERADediting_780533chr19_52948775_-0.0256300502266290.182219350070489.04976940033198e-050.3141360001652320.603622405746383-0.0427304599542782
CERADediting_780539chr19_52948956_-7.57321982363362e-050.3173898408468386.68188765029022e-050.3196551090726030.998517610523038-0.000152976687093033
CERADediting_780548chr19_52949083_-0.0124126417748050.2036987457976471.2378260988255e-060.3838913450681380.0006422693692866150.275568390573891
CERADediting_780549chr19_52949096_-0.002894535392081120.2416187768877396.3896267970161e-070.3933210487423350.0007526995557368490.272192297540113
CERADediting_780550chr19_52949104_-0.0001280154332947750.3076904900084871.43708793808873e-070.4135840062911040.000718382622973470.273189722172462

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
CER1.9937955090265e-090.4652350193352391.71032372238416e-060.379171579220880.006814820530904610.220050514251125
IFG0.0157224858150903-0.4777476468841560.10589773523236-0.3311360527292450.857881077583194-0.0377335701777003
PG1.02178631188886e-090.4287860075971670.01064079269577750.186895525280260.06256691530765670.136826768206152

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Relation with AD stages for ZNF816-ZNF321P

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.
CERADediting_780507chr19_52947118_-0.0009664195165987150.313171095875675
CERADediting_780548chr19_52949083_-0.0008030821169842730.317814031079237

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for ZNF816-ZNF321P

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF816-ZNF321P

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource