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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RPL12P28 |
 Gene summary |
| Gene information | Gene symbol | RPL12P28 | Gene ID | 100271273 |
| Gene name | ribosomal protein L12 pseudogene 28 | |
| Synonyms | RPL12_7_1019 | |
| Cytomap | 10p15.1 | |
| Type of gene | pseudo | |
| Description | - | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RPL12P28 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_198157(5861931, -), ADediting_198158(5861987, -), ADediting_198159(5861991, -), ADediting_198160(5861998, -), ADediting_198161(5861999, -), ADediting_198162(5862013, -), ADediting_198163(5862026, -), ADediting_198164(5862030, -), ADediting_198165(5862034, -), ADediting_198166(5862040, -), ADediting_198167(5862062, -), ADediting_198168(5862066, -), ADediting_198169(5862070, -), ADediting_198170(5862077, -), ADediting_198171(5862080, -), ADediting_198172(5862083, -), ADediting_198173(5862098, -), ADediting_198174(5862099, -), ADediting_198175(5862100, -), ADediting_198176(5862108, -), ADediting_198177(5862123, -), ADediting_198178(5862132, -), ADediting_198179(5862170, -), ADediting_198180(5862175, -), ADediting_198181(5862176, -), ADediting_198182(5862184, -), |
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RNA editing positional annotations for RPL12P28 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_198157 | chr10_5861931_- | ncRNA_intronic |
| ADediting_198158 | chr10_5861987_- | ncRNA_intronic |
| ADediting_198159 | chr10_5861991_- | ncRNA_intronic |
| ADediting_198160 | chr10_5861998_- | ncRNA_intronic |
| ADediting_198161 | chr10_5861999_- | ncRNA_intronic |
| ADediting_198162 | chr10_5862013_- | ncRNA_intronic |
| ADediting_198163 | chr10_5862026_- | ncRNA_intronic |
| ADediting_198164 | chr10_5862030_- | ncRNA_intronic |
| ADediting_198165 | chr10_5862034_- | ncRNA_intronic |
| ADediting_198166 | chr10_5862040_- | ncRNA_intronic |
| ADediting_198167 | chr10_5862062_- | ncRNA_intronic |
| ADediting_198168 | chr10_5862066_- | ncRNA_intronic |
| ADediting_198169 | chr10_5862070_- | ncRNA_intronic |
| ADediting_198170 | chr10_5862077_- | ncRNA_intronic |
| ADediting_198171 | chr10_5862080_- | ncRNA_intronic |
| ADediting_198172 | chr10_5862083_- | ncRNA_intronic |
| ADediting_198173 | chr10_5862098_- | ncRNA_intronic |
| ADediting_198174 | chr10_5862099_- | ncRNA_intronic |
| ADediting_198175 | chr10_5862100_- | ncRNA_intronic |
| ADediting_198176 | chr10_5862108_- | ncRNA_intronic |
| ADediting_198177 | chr10_5862123_- | ncRNA_intronic |
| ADediting_198178 | chr10_5862132_- | ncRNA_intronic |
| ADediting_198179 | chr10_5862170_- | ncRNA_intronic |
| ADediting_198180 | chr10_5862175_- | ncRNA_intronic |
| ADediting_198181 | chr10_5862176_- | ncRNA_intronic |
| ADediting_198182 | chr10_5862184_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_198157 | chr10_5861931_- | SINE | Alu | Name=AluY |
| ADediting_198158 | chr10_5861987_- | SINE | Alu | Name=AluY |
| ADediting_198159 | chr10_5861991_- | SINE | Alu | Name=AluY |
| ADediting_198160 | chr10_5861998_- | SINE | Alu | Name=AluY |
| ADediting_198161 | chr10_5861999_- | SINE | Alu | Name=AluY |
| ADediting_198162 | chr10_5862013_- | SINE | Alu | Name=AluY |
| ADediting_198163 | chr10_5862026_- | SINE | Alu | Name=AluY |
| ADediting_198164 | chr10_5862030_- | SINE | Alu | Name=AluY |
| ADediting_198165 | chr10_5862034_- | SINE | Alu | Name=AluY |
| ADediting_198166 | chr10_5862040_- | SINE | Alu | Name=AluY |
| ADediting_198167 | chr10_5862062_- | SINE | Alu | Name=AluY |
| ADediting_198168 | chr10_5862066_- | SINE | Alu | Name=AluY |
| ADediting_198169 | chr10_5862070_- | SINE | Alu | Name=AluY |
| ADediting_198170 | chr10_5862077_- | SINE | Alu | Name=AluY |
| ADediting_198171 | chr10_5862080_- | SINE | Alu | Name=AluY |
| ADediting_198172 | chr10_5862083_- | SINE | Alu | Name=AluY |
| ADediting_198173 | chr10_5862098_- | SINE | Alu | Name=AluY |
| ADediting_198174 | chr10_5862099_- | SINE | Alu | Name=AluY |
| ADediting_198175 | chr10_5862100_- | SINE | Alu | Name=AluY |
| ADediting_198176 | chr10_5862108_- | SINE | Alu | Name=AluY |
| ADediting_198177 | chr10_5862123_- | SINE | Alu | Name=AluY |
| ADediting_198178 | chr10_5862132_- | SINE | Alu | Name=AluY |
| ADediting_198179 | chr10_5862170_- | SINE | Alu | Name=AluY |
| ADediting_198180 | chr10_5862175_- | SINE | Alu | Name=AluY |
| ADediting_198181 | chr10_5862176_- | SINE | Alu | Name=AluY |
| ADediting_198182 | chr10_5862184_- | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for RPL12P28 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RPL12P28 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RPL12P28 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RPL12P28 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RPL12P28 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RPL12P28 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.42417676304471e-10 | 0.349618721685918 | 9.75347188333629e-14 | 0.406085488554962 | 0.601859256508076 | 0.029745805294913 |
| AC | 6.68402849260681e-32 | 0.65404206174029 | 2.11338487534002e-33 | 0.665891388993067 | 1.1609822900143e-07 | 0.327523068780688 |
| PCC | 4.67554635211053e-26 | 0.668108592279133 | 8.77027970777604e-23 | 0.633040260002395 | 0.0131306260623788 | 0.179182829058998 |
| FP | 6.84787548312446e-06 | 0.32999787445993 | 2.59587801881941e-06 | 0.343928959658897 | 0.00814339737965863 | 0.197761614695044 |
| IFG | 0.0714500944033254 | 0.366618783037754 | 0.0230719910115187 | 0.452684221052851 | 0.0119650059015636 | 0.494563479826001 |
| PG | 9.61360494540908e-05 | 0.282045897860136 | 1.21614607135164e-05 | 0.314700085847136 | 0.587428440125159 | -0.0400368360670882 |
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Relation with AD stages for RPL12P28 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| TCX | 0.00072873058009571 | 0.323134085405676 |
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RelatedDrugs for RPL12P28 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPL12P28 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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