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Center for Computational Systems Medicine
Soverview

Gene summary

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RNA A-to-I events

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Differntial gene expression between RNA A-to-I edited versus non-edited samples

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Protein coding region RNA A-to-I editings

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The effects of the RNA editing to the miRNA binding sites

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The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with AD stages

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Related drugs with this gene

Soverview

Related diseases with this gene


Gene summary for UPK3BL1

check button Gene summary
Gene informationGene symbol

UPK3BL1

Gene ID

100134938

Gene nameuroplakin 3B like 1
SynonymsUPK3BL|UPLP
Cytomap

7q22.1

Type of geneprotein-coding
Descriptionuroplakin-3b-like protein 1uroplakin 3C proteinuroplakin-3-like proteinuroplakin-3b-like proteinuroplakin-like protein
Modification date20200313
UniProtAcc

B0FP48,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for UPK3BL1

check buttonRNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
* This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
all structure

check button RNA editing frequencies across three data sets.
boxplot

check buttonThe number of RNA A-to-I editing events in different types of transcripts (# event, percentage).
boxplot

check button RNA A-to-I editing events in AD.
ADediting_1290973(102637142, -), ADediting_1290974(102637153, -), ADediting_1290975(102637154, -), ADediting_1290976(102637155, -), ADediting_1290977(102637205, -), ADediting_1290978(102637214, -), ADediting_1290979(102637217, -), ADediting_1290980(102637229, -), ADediting_1290981(102637231, -), ADediting_1290982(102637234, -), ADediting_1290983(102637240, -), ADediting_1290984(102637253, -), ADediting_1290985(102637267, -), ADediting_1290986(102637269, -), ADediting_1290987(102637273, -), ADediting_1290988(102637275, -), ADediting_1290989(102637285, -), ADediting_1290990(102637297, -), ADediting_1290991(102637310, -), ADediting_1290992(102637314, -), ADediting_1290993(102637334, -), ADediting_1290994(102637335, -), ADediting_1290995(102637340, -), ADediting_1290996(102638258, -), ADediting_1290997(102638259, -), ADediting_1290998(102638273, -), ADediting_1290999(102638299, -), ADediting_1291000(102638300, -), ADediting_1291001(102638382, -), ADediting_1663264(102637177, -),

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RNA editing positional annotations for UPK3BL1 using Annovar

check button Protein coding RNA editing(s).
ADeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
ADeditome IDPositionVariant type
ADediting_1290973chr7_102637142_-ncRNA_intronic
ADediting_1290974chr7_102637153_-ncRNA_intronic
ADediting_1290975chr7_102637154_-ncRNA_intronic
ADediting_1290976chr7_102637155_-ncRNA_intronic
ADediting_1290977chr7_102637205_-ncRNA_intronic
ADediting_1290978chr7_102637214_-ncRNA_intronic
ADediting_1290979chr7_102637217_-ncRNA_intronic
ADediting_1290980chr7_102637229_-ncRNA_intronic
ADediting_1290981chr7_102637231_-ncRNA_intronic
ADediting_1290982chr7_102637234_-ncRNA_intronic
ADediting_1290983chr7_102637240_-ncRNA_intronic
ADediting_1290984chr7_102637253_-ncRNA_intronic
ADediting_1290985chr7_102637267_-ncRNA_intronic
ADediting_1290986chr7_102637269_-ncRNA_intronic
ADediting_1290987chr7_102637273_-ncRNA_intronic
ADediting_1290988chr7_102637275_-ncRNA_intronic
ADediting_1290989chr7_102637285_-ncRNA_intronic
ADediting_1290990chr7_102637297_-ncRNA_intronic
ADediting_1290991chr7_102637310_-ncRNA_intronic
ADediting_1290992chr7_102637314_-ncRNA_intronic
ADediting_1290993chr7_102637334_-ncRNA_intronic
ADediting_1290994chr7_102637335_-ncRNA_intronic
ADediting_1290995chr7_102637340_-ncRNA_intronic
ADediting_1290996chr7_102638258_-ncRNA_intronic
ADediting_1290997chr7_102638259_-ncRNA_intronic
ADediting_1290998chr7_102638273_-ncRNA_intronic
ADediting_1290999chr7_102638299_-ncRNA_intronic
ADediting_1291000chr7_102638300_-ncRNA_intronic
ADediting_1291001chr7_102638382_-ncRNA_intronic
ADediting_1663264chr7_102637177_-ncRNA_intronic

check button Repat-regional RNA editing(s).
ADeditome IDPositionRepeat familyRepeat sub familyRepeat name
ADediting_1290973chr7_102637142_-SINEAluName=AluSc
ADediting_1290974chr7_102637153_-SINEAluName=AluSc
ADediting_1290975chr7_102637154_-SINEAluName=AluSc
ADediting_1290976chr7_102637155_-SINEAluName=AluSc
ADediting_1290977chr7_102637205_-SINEAluName=AluSc
ADediting_1290978chr7_102637214_-SINEAluName=AluSc
ADediting_1290979chr7_102637217_-SINEAluName=AluSc
ADediting_1290980chr7_102637229_-SINEAluName=AluSc
ADediting_1290981chr7_102637231_-SINEAluName=AluSc
ADediting_1290982chr7_102637234_-SINEAluName=AluSc
ADediting_1290983chr7_102637240_-SINEAluName=AluSc
ADediting_1290984chr7_102637253_-SINEAluName=AluSc
ADediting_1290985chr7_102637267_-SINEAluName=AluSc
ADediting_1290986chr7_102637269_-SINEAluName=AluSc
ADediting_1290987chr7_102637273_-SINEAluName=AluSc
ADediting_1290988chr7_102637275_-SINEAluName=AluSc
ADediting_1290989chr7_102637285_-SINEAluName=AluSc
ADediting_1290990chr7_102637297_-SINEAluName=AluSc
ADediting_1290991chr7_102637310_-SINEAluName=AluSc
ADediting_1290992chr7_102637314_-SINEAluName=AluSc
ADediting_1290993chr7_102637334_-SINEAluName=AluSc
ADediting_1290994chr7_102637335_-SINEAluName=AluSc
ADediting_1290995chr7_102637340_-SINEAluName=AluSc
ADediting_1290996chr7_102638258_-SINEAluName=AluSx
ADediting_1290997chr7_102638259_-SINEAluName=AluSx
ADediting_1290998chr7_102638273_-SINEAluName=AluSx
ADediting_1290999chr7_102638299_-SINEAluName=AluSx
ADediting_1291000chr7_102638300_-SINEAluName=AluSx
ADediting_1291001chr7_102638382_-SINEAluName=AluSx
ADediting_1663264chr7_102637177_-SINEAluName=AluSc

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RNA A-to-I editing events in the alternative splicing sites for UPK3BL1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeADeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UPK3BL1

check button Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event.
* The grey color means N/A.

check button Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
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check button - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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ADeditome IDChrPositoingSkipped exonENSGENSTs

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Protein coding region RNA A-to-I editings for UPK3BL1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for UPK3BL1

check buttonRNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure.
all structure

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1290974chr7_102637153_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-383-3pchr71026371481026371547mer-m8102637147102637165140-16.5
ADediting_1290976chr7_102637155_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-3192-5pchr71026371541026371618mer-1a102637154102637175154-29.74
ADediting_1290976chr7_102637155_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-4314chr71026371531026371608mer-1a102637153102637170140-17.23
ADediting_1290978chr7_102637214_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-433-5pchr71026372131026372197mer-m8102637212102637235159-23.87
ADediting_1290986chr7_102637269_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6720-3pchr71026372671026372748mer-1a102637267102637288152-21.15
ADediting_1290988chr7_102637275_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-17-3pchr71026372721026372787mer-m8102637271102637293150-22.27
ADediting_1290989chr7_102637285_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-4691-3pchr71026372811026372877mer-m8102637280102637306148-24.72
ADediting_1290990chr7_102637297_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6089chr71026372921026372987mer-m8102637291102637314160-35.06
ADediting_1290991chr7_102637310_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-548at-3pchr71026373061026373127mer-m8102637305102637325155-14.5
ADediting_1290991chr7_102637310_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-548ay-3pchr71026373061026373127mer-m8102637305102637326156-17.33
ADediting_1290992chr7_102637314_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6078chr71026373101026373178mer-1a102637310102637327150-22.83
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-17-3pchr71026373341026373407mer-m8102637333102637353153-18.99
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-485-5pchr71026373301026373367mer-m8102637329102637349153-19.66
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6884-5pchr71026373301026373367mer-m8102637329102637351146-21.96

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
ADediting_1290974chr7_102637153_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-4310chr71026371481026371547mer-m8102637147102637162140-8.38
ADediting_1290974chr7_102637153_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-7157-5pchr71026371481026371547mer-m8102637147102637167149-18.74
ADediting_1290976chr7_102637155_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-887-5pchr71026371541026371618mer-1a102637154102637175150-15.15
ADediting_1290977chr7_102637205_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-3190-5pchr71026372041026372107mer-m8102637203102637222147-18.34
ADediting_1290977chr7_102637205_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-548schr71026372051026372117mer-m8102637204102637225143-12.53
ADediting_1290980chr7_102637229_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-3675-3pchr71026372261026372327mer-m8102637225102637246145-12.58
ADediting_1290981chr7_102637231_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-3675-3pchr71026372261026372327mer-m8102637225102637246145-12.58
ADediting_1290984chr7_102637253_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-1285-3pchr71026372521026372587mer-m8102637251102637272140-16.14
ADediting_1290984chr7_102637253_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-4487chr71026372481026372558mer-1a102637248102637267144-18.15
ADediting_1290984chr7_102637253_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-5189-5pchr71026372521026372587mer-m8102637251102637276145-23.05
ADediting_1290984chr7_102637253_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-612chr71026372521026372587mer-m8102637251102637276152-25.15
ADediting_1290985chr7_102637267_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550b-2-5pchr71026372671026372737mer-m8102637266102637287148-17.84
ADediting_1290986chr7_102637269_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550a-3-5pchr71026372671026372748mer-1a102637267102637286143-16.2
ADediting_1290986chr7_102637269_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550a-5pchr71026372671026372748mer-1a102637267102637289143-18.46
ADediting_1290986chr7_102637269_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550b-2-5pchr71026372671026372737mer-m8102637266102637287148-17.84
ADediting_1290987chr7_102637273_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-20b-3pchr71026372721026372787mer-m8102637271102637293153-18.04
ADediting_1290987chr7_102637273_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550a-3-5pchr71026372671026372748mer-1a102637267102637286143-16.2
ADediting_1290987chr7_102637273_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-550a-5pchr71026372671026372748mer-1a102637267102637289143-18.46
ADediting_1290988chr7_102637275_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-20b-3pchr71026372721026372787mer-m8102637271102637293153-18.04
ADediting_1290989chr7_102637285_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-5690chr71026372811026372877mer-m8102637280102637300145-17.72
ADediting_1290990chr7_102637297_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-4478chr71026372931026372997mer-m8102637292102637307145-21.77
ADediting_1290990chr7_102637297_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-485-5pchr71026372921026372987mer-m8102637291102637312149-17.29
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-377-5pchr71026373301026373367mer-m8102637329102637350155-19.35
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6086chr71026373301026373367mer-m8102637329102637348148-19
ADediting_1290993chr7_102637334_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6516-5pchr71026373341026373407mer-m8102637333102637356147-16.38
ADediting_1290994chr7_102637335_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-377-5pchr71026373301026373367mer-m8102637329102637350155-19.35
ADediting_1290994chr7_102637335_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6086chr71026373301026373367mer-m8102637329102637348148-19
ADediting_1290994chr7_102637335_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6516-5pchr71026373341026373407mer-m8102637333102637356147-16.38
ADediting_1290995chr7_102637340_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-6807-5pchr71026373401026373467mer-m8102637339102637360141-19.93
ADediting_1663264chr7_102637177_-ENSG00000267368.1ENST00000340457.8UPK3BL1-201hsa-miR-513b-5pchr71026371771026371837mer-m8102637176102637197146-16.03

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
ADeditom_IDPositionENSGENSTTranscript namemiRNA IDChromosomeTargtTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network
Differentially expressed mRNA-miRNA network
boxplot

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The effects of the RNA editing to the stability of the RNA structures for UPK3BL1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000340457.8protein_codingSoverviewSoverview

check button RNA A-to-I editing in miRNA.
ADeditom_IDENSTmir_IDEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

check button RNA A-to-I editing in mRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
ADediting_1290973ENST00000340457.8chr7_102637142_-1225-534.10-532.60-558.40
ADediting_1290974ENST00000340457.8chr7_102637153_-1214-533.50-532.60-558.40
ADediting_1290975ENST00000340457.8chr7_102637154_-1213-534.00-532.60-558.40
ADediting_1290976ENST00000340457.8chr7_102637155_-1212-535.30-532.60-558.40
ADediting_1663264ENST00000340457.8chr7_102637177_-1190-535.40-532.60-558.40
ADediting_1290977ENST00000340457.8chr7_102637205_-1162-533.70-532.60-558.40
ADediting_1290978ENST00000340457.8chr7_102637214_-1153-533.50-532.60-558.40
ADediting_1290979ENST00000340457.8chr7_102637217_-1150-535.00-532.60-558.40
ADediting_1290980ENST00000340457.8chr7_102637229_-1138-532.50-532.60-558.40
ADediting_1290981ENST00000340457.8chr7_102637231_-1136-533.90-532.60-558.40
ADediting_1290982ENST00000340457.8chr7_102637234_-1133-533.80-532.60-558.40
ADediting_1290983ENST00000340457.8chr7_102637240_-1127-533.00-532.60-558.40
ADediting_1290984ENST00000340457.8chr7_102637253_-1114-531.90-532.60-558.40
ADediting_1290985ENST00000340457.8chr7_102637267_-1100-532.60-532.60-558.40
ADediting_1290986ENST00000340457.8chr7_102637269_-1098-532.60-532.60-558.40
ADediting_1290987ENST00000340457.8chr7_102637273_-1094-533.40-532.60-558.40
ADediting_1290988ENST00000340457.8chr7_102637275_-1092-534.40-532.60-558.40
ADediting_1290989ENST00000340457.8chr7_102637285_-1082-532.60-532.60-558.40
ADediting_1290990ENST00000340457.8chr7_102637297_-1070-532.50-532.60-558.40
ADediting_1290991ENST00000340457.8chr7_102637310_-1057-535.50-532.60-558.40
ADediting_1290992ENST00000340457.8chr7_102637314_-1053-532.30-532.60-558.40
ADediting_1290993ENST00000340457.8chr7_102637334_-1033-534.60-532.60-558.40
ADediting_1290994ENST00000340457.8chr7_102637335_-1032-532.80-532.60-558.40
ADediting_1290995ENST00000340457.8chr7_102637340_-1027-534.70-532.60-558.40

check button RNA A-to-I editing in lncRNA.
ADeditom_IDENSTEditing_InformationEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for UPK3BL1

check button Correlation between ADAR gene expression and RNA editing frequency
TissueADeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

check button Correlation between ADAR gene expression and this gene's expression
TissueADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
DLPFC0.0006252841179347210.1932126909945040.6404270423765620.02663248219134621.1102709176059e-390.65702223701777
AC1.52013546834555e-140.4607827701418252.03706208494163e-110.4074585251521067.27243809718757e-090.355599146189375
FP2.11157720885305e-050.3129197467257881.54717557183768e-050.3177410495935431.90913782558793e-050.314491265955077
STG0.03414275504463690.2314539818430570.5986150024328860.05825832872683299.60519532178628e-060.462189559069217

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Relation with AD stages for UPK3BL1

check button Correlation between AD stages and RNA editing frequency
TissueADeditomIDpositionP-valCoeff.

check button Correlation between AD stages and this gene's expression
TissueP-valCoeff.

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RelatedDrugs for UPK3BL1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UPK3BL1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource