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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for RASA4DP |
 Gene summary |
| Gene information | Gene symbol | RASA4DP | Gene ID | 100133005 |
| Gene name | RAS p21 protein activator 4CD, pseudogene | |
| Synonyms | - | |
| Cytomap | 7q22.1 | |
| Type of gene | pseudo | |
| Description | RAS p21 protein activator 4 pseudogene | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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RNA A-to-I events for RASA4DP |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_1291116(102683751, -), ADediting_1291117(102683752, -), ADediting_1291118(102683756, -), ADediting_1291119(102683798, -), ADediting_1291120(102683822, -), ADediting_1291121(102683848, -), ADediting_1291122(102683852, -), ADediting_1291123(102683853, -), ADediting_1291124(102683855, -), ADediting_1291125(102683860, -), ADediting_1291126(102683861, -), ADediting_1291127(102683864, -), ADediting_1291128(102683884, -), ADediting_1291129(102683888, -), ADediting_1291130(102683955, -), ADediting_1291131(102683956, -), ADediting_1291132(102683964, -), ADediting_1291133(102684997, -), ADediting_1291134(102685003, -), ADediting_1291135(102686404, -), ADediting_1585337(102683879, -), |
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RNA editing positional annotations for RASA4DP using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_1291116 | chr7_102683751_- | ncRNA_intronic |
| ADediting_1291117 | chr7_102683752_- | ncRNA_intronic |
| ADediting_1291118 | chr7_102683756_- | ncRNA_intronic |
| ADediting_1291119 | chr7_102683798_- | ncRNA_intronic |
| ADediting_1291120 | chr7_102683822_- | ncRNA_intronic |
| ADediting_1291121 | chr7_102683848_- | ncRNA_intronic |
| ADediting_1291122 | chr7_102683852_- | ncRNA_intronic |
| ADediting_1291123 | chr7_102683853_- | ncRNA_intronic |
| ADediting_1291124 | chr7_102683855_- | ncRNA_intronic |
| ADediting_1291125 | chr7_102683860_- | ncRNA_intronic |
| ADediting_1291126 | chr7_102683861_- | ncRNA_intronic |
| ADediting_1291127 | chr7_102683864_- | ncRNA_intronic |
| ADediting_1291128 | chr7_102683884_- | ncRNA_intronic |
| ADediting_1291129 | chr7_102683888_- | ncRNA_intronic |
| ADediting_1291130 | chr7_102683955_- | ncRNA_intronic |
| ADediting_1291131 | chr7_102683956_- | ncRNA_intronic |
| ADediting_1291132 | chr7_102683964_- | ncRNA_intronic |
| ADediting_1291133 | chr7_102684997_- | ncRNA_intronic |
| ADediting_1291134 | chr7_102685003_- | ncRNA_intronic |
| ADediting_1291135 | chr7_102686404_- | ncRNA_intronic |
| ADediting_1585337 | chr7_102683879_- | ncRNA_intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_1291116 | chr7_102683751_- | SINE | Alu | Name=AluY |
| ADediting_1291117 | chr7_102683752_- | SINE | Alu | Name=AluY |
| ADediting_1291118 | chr7_102683756_- | SINE | Alu | Name=AluY |
| ADediting_1291119 | chr7_102683798_- | SINE | Alu | Name=AluY |
| ADediting_1291120 | chr7_102683822_- | SINE | Alu | Name=AluY |
| ADediting_1291121 | chr7_102683848_- | SINE | Alu | Name=AluY |
| ADediting_1291122 | chr7_102683852_- | SINE | Alu | Name=AluY |
| ADediting_1291123 | chr7_102683853_- | SINE | Alu | Name=AluY |
| ADediting_1291124 | chr7_102683855_- | SINE | Alu | Name=AluY |
| ADediting_1291125 | chr7_102683860_- | SINE | Alu | Name=AluY |
| ADediting_1291126 | chr7_102683861_- | SINE | Alu | Name=AluY |
| ADediting_1291127 | chr7_102683864_- | SINE | Alu | Name=AluY |
| ADediting_1291128 | chr7_102683884_- | SINE | Alu | Name=AluY |
| ADediting_1291129 | chr7_102683888_- | SINE | Alu | Name=AluY |
| ADediting_1291130 | chr7_102683955_- | SINE | Alu | Name=AluY |
| ADediting_1291131 | chr7_102683956_- | SINE | Alu | Name=AluY |
| ADediting_1291132 | chr7_102683964_- | SINE | Alu | Name=AluY |
| ADediting_1291133 | chr7_102684997_- | SINE | Alu | Name=AluSx |
| ADediting_1291134 | chr7_102685003_- | SINE | Alu | Name=AluSx |
| ADediting_1291135 | chr7_102686404_- | SINE | Alu | Name=AluSx1 |
| ADediting_1585337 | chr7_102683879_- | SINE | Alu | Name=AluY |
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RNA A-to-I editing events in the alternative splicing sites for RASA4DP |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RASA4DP |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for RASA4DP |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for RASA4DP |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for RASA4DP |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for RASA4DP |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_1291119 | chr7_102683798_- | 0.0889067320649724 | 0.0967853100628796 | 0.602143029447496 | 0.0297225842700241 | 2.42824395817129e-08 | 0.310230668162303 |
| CER | ADediting_1291121 | chr7_102683848_- | 0.984665583937405 | -0.00158254617075074 | 0.0425313712339745 | 0.165847309860269 | 2.64846298253335e-05 | 0.335862356130536 |
| DLPFC | ADediting_1291133 | chr7_102684997_- | 0.0725023375773351 | -0.102148838016491 | 0.00173430202349811 | -0.17720967274836 | 5.92410535067594e-09 | 0.322900263810228 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 2.7414709069992e-10 | 0.348636157737936 | 1.49376791383133e-09 | 0.334732534713426 | 2.95673240576811e-30 | 0.588327729795907 |
| CER | 1.534336316732e-08 | 0.441665405124729 | 2.49140217495902e-10 | 0.487547126815544 | 1.39867158820423e-05 | 0.346536962283029 |
| TCX | 9.15648937026868e-06 | 0.353411151228471 | 0.00593705905506704 | 0.223655662666879 | 0.488425111195202 | 0.056998988484048 |
| FP | 2.872792701993e-06 | 0.342504418328567 | 0.0125413896512125 | 0.186789165676962 | 6.9210232470283e-11 | 0.463946018344056 |
| IFG | 0.0192927740601997 | 0.46459611032258 | 0.00217626971982338 | 0.583998031549701 | 0.023147050501636 | 0.452464205670527 |
| STG | 0.000111161145744415 | 0.409199945376694 | 0.0296139474304473 | 0.237487341501677 | 1.67584092752632e-10 | 0.62757377429886 |
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Relation with AD stages for RASA4DP |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| CER | ADediting_1291117 | chr7_102683752_- | 0.00116710298659014 | 0.308361651621111 |
| CER | ADediting_1291120 | chr7_102683822_- | 0.000521782720796774 | 0.328350128981921 |
| CER | ADediting_1291121 | chr7_102683848_- | 2.93757770762704e-05 | 0.390512041100951 |
| CER | ADediting_1291125 | chr7_102683860_- | 0.000376483792497665 | 0.336081666644383 |
| CER | ADediting_1291128 | chr7_102683884_- | 9.74512472525563e-06 | 0.411367588387079 |
| CER | ADediting_1291129 | chr7_102683888_- | 6.12786140471825e-05 | 0.375792385390485 |
| CER | ADediting_1291132 | chr7_102683964_- | 0.00117005191140871 | 0.308296782442516 |
| TCX | ADediting_1291131 | chr7_102683956_- | 0.000808740660084905 | 0.320531493839878 |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 3.2456638992437e-07 | 0.468111792025805 |
| TCX | 8.78172280807439e-05 | 0.371609355522825 |
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RelatedDrugs for RASA4DP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RASA4DP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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