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| Differntial gene expression between RNA A-to-I edited versus non-edited samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Gene summary for AKT3 |
 Gene summary |
| Gene information | Gene symbol | AKT3 | Gene ID | 10000 |
| Gene name | AKT serine/threonine kinase 3 | |
| Synonyms | MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 | |
| Cytomap | 1q43-q44 | |
| Type of gene | protein-coding | |
| Description | RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | |
| Modification date | 20200313 | |
| UniProtAcc | Q9Y243, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| AKT3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 28254819 |
| AKT3 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 28254819 |
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RNA A-to-I events for AKT3 |
| RNA A-to-I editing events in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. * This pie chart shows the number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA editing frequencies across three data sets. |
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| The number of RNA A-to-I editing events in different types of transcripts (# event, percentage). |
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| RNA A-to-I editing events in AD. |
| ADediting_82981(243612784, -), ADediting_82982(243612796, -), ADediting_82983(243612797, -), ADediting_82984(243612806, -), ADediting_82985(243612873, -), ADediting_82986(243612876, -), ADediting_82987(243612927, -), ADediting_82988(243612939, -), ADediting_82989(243612952, -), ADediting_82990(243612956, -), ADediting_82991(243612957, -), ADediting_82992(243612979, -), ADediting_82993(243612987, -), ADediting_82994(243612993, -), ADediting_82995(243612998, -), ADediting_83001(243797943, -), ADediting_83002(243797945, -), ADediting_83003(243797991, -), ADediting_83004(243797994, -), ADediting_83005(243797998, -), ADediting_83006(243798011, -), ADediting_83007(243798021, -), ADediting_83008(243800445, -), ADediting_83009(243800463, -), ADediting_83010(243800475, -), ADediting_83011(243800490, -), ADediting_1518196(243612995, -), ADediting_1599990(243843784, -), ADediting_1599991(243843790, -), |
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RNA editing positional annotations for AKT3 using Annovar |
| Protein coding RNA editing(s). |
| ADeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| ADeditome ID | Position | Variant type |
| ADediting_82981 | chr1_243612784_- | intronic |
| ADediting_82982 | chr1_243612796_- | intronic |
| ADediting_82983 | chr1_243612797_- | intronic |
| ADediting_82984 | chr1_243612806_- | intronic |
| ADediting_82985 | chr1_243612873_- | intronic |
| ADediting_82986 | chr1_243612876_- | intronic |
| ADediting_82987 | chr1_243612927_- | intronic |
| ADediting_82988 | chr1_243612939_- | intronic |
| ADediting_82989 | chr1_243612952_- | intronic |
| ADediting_82990 | chr1_243612956_- | intronic |
| ADediting_82991 | chr1_243612957_- | intronic |
| ADediting_82992 | chr1_243612979_- | intronic |
| ADediting_82993 | chr1_243612987_- | intronic |
| ADediting_82994 | chr1_243612993_- | intronic |
| ADediting_82995 | chr1_243612998_- | intronic |
| ADediting_83001 | chr1_243797943_- | intronic |
| ADediting_83002 | chr1_243797945_- | intronic |
| ADediting_83003 | chr1_243797991_- | intronic |
| ADediting_83004 | chr1_243797994_- | intronic |
| ADediting_83005 | chr1_243797998_- | intronic |
| ADediting_83006 | chr1_243798011_- | intronic |
| ADediting_83007 | chr1_243798021_- | intronic |
| ADediting_83008 | chr1_243800445_- | intronic |
| ADediting_83009 | chr1_243800463_- | intronic |
| ADediting_83010 | chr1_243800475_- | intronic |
| ADediting_83011 | chr1_243800490_- | intronic |
| ADediting_1518196 | chr1_243612995_- | intronic |
| ADediting_1599990 | chr1_243843784_- | intronic |
| ADediting_1599991 | chr1_243843790_- | intronic |
| Repat-regional RNA editing(s). |
| ADeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| ADediting_82981 | chr1_243612784_- | SINE | Alu | Name=AluSc |
| ADediting_82982 | chr1_243612796_- | SINE | Alu | Name=AluSc |
| ADediting_82983 | chr1_243612797_- | SINE | Alu | Name=AluSc |
| ADediting_82984 | chr1_243612806_- | SINE | Alu | Name=AluSc |
| ADediting_82985 | chr1_243612873_- | SINE | Alu | Name=AluSc |
| ADediting_82986 | chr1_243612876_- | SINE | Alu | Name=AluSc |
| ADediting_82987 | chr1_243612927_- | SINE | Alu | Name=AluSc |
| ADediting_82988 | chr1_243612939_- | SINE | Alu | Name=AluSc |
| ADediting_82989 | chr1_243612952_- | SINE | Alu | Name=AluSc |
| ADediting_82990 | chr1_243612956_- | SINE | Alu | Name=AluSc |
| ADediting_82991 | chr1_243612957_- | SINE | Alu | Name=AluSc |
| ADediting_82992 | chr1_243612979_- | SINE | Alu | Name=AluSc |
| ADediting_82993 | chr1_243612987_- | SINE | Alu | Name=AluSc |
| ADediting_82994 | chr1_243612993_- | SINE | Alu | Name=AluSc |
| ADediting_82995 | chr1_243612998_- | SINE | Alu | Name=AluSc |
| ADediting_83001 | chr1_243797943_- | SINE | Alu | Name=AluY |
| ADediting_83002 | chr1_243797945_- | SINE | Alu | Name=AluY |
| ADediting_83003 | chr1_243797991_- | SINE | Alu | Name=AluY |
| ADediting_83004 | chr1_243797994_- | SINE | Alu | Name=AluY |
| ADediting_83005 | chr1_243797998_- | SINE | Alu | Name=AluY |
| ADediting_83006 | chr1_243798011_- | SINE | Alu | Name=AluY |
| ADediting_83007 | chr1_243798021_- | SINE | Alu | Name=AluY |
| ADediting_83008 | chr1_243800445_- | SINE | Alu | Name=AluSc |
| ADediting_83009 | chr1_243800463_- | SINE | Alu | Name=AluSc |
| ADediting_83010 | chr1_243800475_- | SINE | Alu | Name=AluSc |
| ADediting_83011 | chr1_243800490_- | SINE | Alu | Name=AluSc |
| ADediting_1518196 | chr1_243612995_- | SINE | Alu | Name=AluSc |
| ADediting_1599990 | chr1_243843784_- | SINE | Alu | Name=AluSx4 |
| ADediting_1599991 | chr1_243843790_- | SINE | Alu | Name=AluSx4 |
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RNA A-to-I editing events in the alternative splicing sites for AKT3 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | ADeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential pencent of spliced in (PSI) between RNA A-to-I edited and non-edited samples |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AKT3 |
| Distribution of the averaged gene expression in AD and control with or without RNA A-to-I editing event. * The grey color means N/A. |
| Distribution of the averaged gene isoform expression in AD and control with or without RNA A-to-I editing event. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
| - Differentially expressed transcript between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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| ADeditome ID | Chr | Positoing | Skipped exon | ENSG | ENSTs |
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Protein coding region RNA A-to-I editings for AKT3 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for AKT3 |
| RNA A-to-I editings in the ROSMAP, MSBB, and Mayo data sets based on Ensembl gene isoform structure. |
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| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_82982 | chr1_243612796_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-3189-3p | chr1 | 243612795 | 243612801 | 7mer-m8 | 243612794 | 243612813 | 149 | -25.49 |
| ADediting_82982 | chr1_243612796_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-6813-3p | chr1 | 243612794 | 243612800 | 7mer-m8 | 243612793 | 243612813 | 140 | -11.59 |
| ADediting_82983 | chr1_243612797_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-326 | chr1 | 243612795 | 243612801 | 7mer-m8 | 243612794 | 243612813 | 140 | -13.96 |
| ADediting_82983 | chr1_243612797_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-330-5p | chr1 | 243612795 | 243612801 | 7mer-m8 | 243612794 | 243612817 | 143 | -20.22 |
| ADediting_82983 | chr1_243612797_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4314 | chr1 | 243612796 | 243612802 | 7mer-m8 | 243612795 | 243612813 | 143 | -24.03 |
| ADediting_82983 | chr1_243612797_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-514a-5p | chr1 | 243612794 | 243612800 | 7mer-m8 | 243612793 | 243612816 | 150 | -18.62 |
| ADediting_82984 | chr1_243612806_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-6089 | chr1 | 243612801 | 243612807 | 7mer-m8 | 243612800 | 243612822 | 160 | -36.54 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-128-1-5p | chr1 | 243612934 | 243612940 | 7mer-m8 | 243612933 | 243612955 | 149 | -21.7 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-128-2-5p | chr1 | 243612934 | 243612940 | 7mer-m8 | 243612933 | 243612955 | 149 | -25.57 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-6877-5p | chr1 | 243612935 | 243612941 | 7mer-m8 | 243612934 | 243612956 | 154 | -26.49 |
| ADediting_82989 | chr1_243612952_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-589-5p | chr1 | 243612947 | 243612953 | 7mer-m8 | 243612946 | 243612967 | 152 | -15.04 |
| ADediting_82990 | chr1_243612956_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-6078 | chr1 | 243612952 | 243612959 | 8mer-1a | 243612952 | 243612970 | 149 | -20.85 |
| ADediting_82992 | chr1_243612979_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-34a-5p | chr1 | 243612976 | 243612982 | 7mer-1a | 243612976 | 243612998 | 146 | -21.72 |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_82983 | chr1_243612797_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-887-5p | chr1 | 243612796 | 243612803 | 8mer-1a | 243612796 | 243612817 | 145 | -16.87 |
| ADediting_82984 | chr1_243612806_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4478 | chr1 | 243612802 | 243612808 | 7mer-m8 | 243612801 | 243612818 | 150 | -23.07 |
| ADediting_82984 | chr1_243612806_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4649-3p | chr1 | 243612805 | 243612811 | 7mer-m8 | 243612804 | 243612824 | 140 | -12.28 |
| ADediting_82984 | chr1_243612806_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-7160-5p | chr1 | 243612804 | 243612810 | 7mer-m8 | 243612803 | 243612823 | 141 | -16.06 |
| ADediting_82985 | chr1_243612873_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-3675-3p | chr1 | 243612868 | 243612874 | 7mer-m8 | 243612867 | 243612888 | 145 | -12.58 |
| ADediting_82987 | chr1_243612927_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-606 | chr1 | 243612924 | 243612930 | 7mer-m8 | 243612923 | 243612943 | 140 | -6.88 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-185-3p | chr1 | 243612934 | 243612940 | 7mer-m8 | 243612933 | 243612954 | 141 | -16.28 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4649-3p | chr1 | 243612938 | 243612944 | 7mer-m8 | 243612937 | 243612957 | 140 | -14.11 |
| ADediting_82988 | chr1_243612939_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-7160-5p | chr1 | 243612937 | 243612943 | 7mer-m8 | 243612936 | 243612956 | 146 | -20.4 |
| ADediting_82992 | chr1_243612979_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4536-5p | chr1 | 243612975 | 243612981 | 7mer-m8 | 243612974 | 243612993 | 141 | -11.94 |
| ADediting_82993 | chr1_243612987_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-4760-5p | chr1 | 243612987 | 243612993 | 7mer-m8 | 243612986 | 243613007 | 145 | -11.33 |
| ADediting_82993 | chr1_243612987_- | ENSG00000117020.18 | ENST00000492957.1 | AKT3-208 | hsa-miR-8061 | chr1 | 243612987 | 243612993 | 7mer-m8 | 243612986 | 243613006 | 140 | -12.33 |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-5688 | chr1 | 243500608 | 243500615 | 8mer-1a | 243500608 | 243500626 | 153 | -16.55 |
| ADediting_1097295 | chr3_85385762_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-5688 | chr1 | 243500608 | 243500615 | 8mer-1a | 243500608 | 243500626 | 153 | -16.55 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-589-3p | chr1 | 243501345 | 243501351 | 7mer-m8 | 243501344 | 243501364 | 141 | -13.44 |
| ADediting_1337757 | chr7_5495852_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-589-3p | chr1 | 243501345 | 243501351 | 7mer-m8 | 243501344 | 243501364 | 141 | -13.44 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-381-3p | chr1 | 243503026 | 243503032 | 7mer-m8 | 243503025 | 243503044 | 148 | -12.38 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-381-3p | chr1 | 243503026 | 243503032 | 7mer-m8 | 243503025 | 243503044 | 148 | -12.38 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-381-3p | chr1 | 243503026 | 243503032 | 7mer-m8 | 243503025 | 243503044 | 148 | -12.38 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-381-3p | chr1 | 243503026 | 243503032 | 7mer-m8 | 243503025 | 243503044 | 148 | -12.38 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-641 | chr1 | 243504261 | 243504267 | 7mer-m8 | 243504260 | 243504282 | 152 | -14.92 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-641 | chr1 | 243504261 | 243504267 | 7mer-m8 | 243504260 | 243504282 | 152 | -14.92 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-641 | chr1 | 243504261 | 243504267 | 7mer-m8 | 243504260 | 243504282 | 152 | -14.92 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-641 | chr1 | 243504261 | 243504267 | 7mer-m8 | 243504260 | 243504282 | 152 | -14.92 |
| ADediting_286380 | chr11_79422188_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-5579-3p | chr1 | 243503739 | 243503745 | 7mer-m8 | 243503738 | 243503760 | 147 | -12.21 |
| ADediting_286380 | chr11_79422188_- | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-5579-3p | chr1 | 243503739 | 243503745 | 7mer-m8 | 243503738 | 243503760 | 147 | -12.21 |
| ADediting_286380 | chr11_79422188_- | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-5579-3p | chr1 | 243503739 | 243503745 | 7mer-m8 | 243503738 | 243503760 | 147 | -12.21 |
| ADediting_286380 | chr11_79422188_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-5579-3p | chr1 | 243503739 | 243503745 | 7mer-m8 | 243503738 | 243503760 | 147 | -12.21 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-4775 | chr1 | 243500063 | 243500069 | 7mer-m8 | 243500062 | 243500083 | 144 | -6.44 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-4775 | chr1 | 243500063 | 243500069 | 7mer-m8 | 243500062 | 243500083 | 144 | -6.44 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| ADeditom_ID | Position | ENSG | ENST | Transcript name | miRNA ID | Chromosome | Targt | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| ADediting_1337757 | chr7_5495852_- | ENSG00000117020.18 | ENST00000336199.9 | AKT3-202 | hsa-miR-589-3p | chr1 | 243488361 | 243488367 | 7mer-m8 | 243488360 | 243488383 | 145 | -14.31 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-151a-3p | chr1 | 243505028 | 243505035 | 8mer-1a | 243505028 | 243505048 | 145 | -11.96 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-151a-3p | chr1 | 243505028 | 243505035 | 8mer-1a | 243505028 | 243505048 | 145 | -11.96 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-151a-3p | chr1 | 243505028 | 243505035 | 8mer-1a | 243505028 | 243505048 | 145 | -11.96 |
| ADediting_1391023 | chr8_140732605_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-151a-3p | chr1 | 243505028 | 243505035 | 8mer-1a | 243505028 | 243505048 | 145 | -11.96 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-4477b | chr1 | 243500177 | 243500183 | 7mer-m8 | 243500176 | 243500199 | 146 | -12.02 |
| ADediting_1471003 | chr9_63819626_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-4477b | chr1 | 243500177 | 243500183 | 7mer-m8 | 243500176 | 243500199 | 146 | -12.02 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-4477b | chr1 | 243500177 | 243500183 | 7mer-m8 | 243500176 | 243500199 | 146 | -12.02 |
| ADediting_1471004 | chr9_63819627_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-4477b | chr1 | 243500177 | 243500183 | 7mer-m8 | 243500176 | 243500199 | 146 | -12.02 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-381-3p | chr1 | 243501652 | 243501659 | 8mer-1a | 243501652 | 243501673 | 145 | -14.43 |
| ADediting_1535953 | chr14_101045971_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-381-3p | chr1 | 243501652 | 243501659 | 8mer-1a | 243501652 | 243501673 | 145 | -14.43 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-381-3p | chr1 | 243501652 | 243501659 | 8mer-1a | 243501652 | 243501673 | 145 | -14.43 |
| ADediting_1535954 | chr14_101045974_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-381-3p | chr1 | 243501652 | 243501659 | 8mer-1a | 243501652 | 243501673 | 145 | -14.43 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1556067 | chr19_40282625_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1631458 | chr19_40282624_- | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-641 | chr1 | 243503344 | 243503351 | 8mer-1a | 243503344 | 243503369 | 152 | -12.79 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000117020.18 | ENST00000263826.11 | AKT3-201 | hsa-miR-5682 | chr1 | 243503575 | 243503581 | 7mer-m8 | 243503574 | 243503595 | 143 | -13.82 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000117020.18 | ENST00000366539.6 | AKT3-203 | hsa-miR-5682 | chr1 | 243503575 | 243503581 | 7mer-m8 | 243503574 | 243503595 | 143 | -13.82 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000117020.18 | ENST00000672578.1 | AKT3-214 | hsa-miR-5682 | chr1 | 243503575 | 243503581 | 7mer-m8 | 243503574 | 243503595 | 143 | -13.82 |
| ADediting_1643790 | chr3_121049689_+ | ENSG00000117020.18 | ENST00000673466.1 | AKT3-217 | hsa-miR-5682 | chr1 | 243503575 | 243503581 | 7mer-m8 | 243503574 | 243503595 | 143 | -13.82 |
| ADediting_843620 | chr2_207754818_+ | ENSG00000117020.18 | ENST00000491219.6 | AKT3-207 | hsa-miR-4775 | chr1 | 243687790 | 243687796 | 7mer-m8 | 243687789 | 243687810 | 145 | -5.75 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for AKT3 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| ENST00000492957.1 | lncRNA |  |  |
| RNA A-to-I editing in miRNA. |
| ADeditom_ID | ENST | mir_ID | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in mRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| RNA A-to-I editing in lncRNA. |
| ADeditom_ID | ENST | Editing_Information | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
| ADediting_82981 | ENST00000492957.1 | chr1_243612784_- | 371 | -172.70 | -172.50 | -195.10 |
| ADediting_82982 | ENST00000492957.1 | chr1_243612796_- | 359 | -172.80 | -172.50 | -195.10 |
| ADediting_82983 | ENST00000492957.1 | chr1_243612797_- | 358 | -175.00 | -172.50 | -195.10 |
| ADediting_82984 | ENST00000492957.1 | chr1_243612806_- | 349 | -172.80 | -172.50 | -195.10 |
| ADediting_82985 | ENST00000492957.1 | chr1_243612873_- | 282 | -174.30 | -172.50 | -195.10 |
| ADediting_82986 | ENST00000492957.1 | chr1_243612876_- | 279 | -173.80 | -172.50 | -195.10 |
| ADediting_82987 | ENST00000492957.1 | chr1_243612927_- | 228 | -173.10 | -172.50 | -195.10 |
| ADediting_82988 | ENST00000492957.1 | chr1_243612939_- | 216 | -172.50 | -172.50 | -195.10 |
| ADediting_82989 | ENST00000492957.1 | chr1_243612952_- | 203 | -170.20 | -172.50 | -195.10 |
| ADediting_82990 | ENST00000492957.1 | chr1_243612956_- | 199 | -174.30 | -172.50 | -195.10 |
| ADediting_82991 | ENST00000492957.1 | chr1_243612957_- | 198 | -175.90 | -172.50 | -195.10 |
| ADediting_82992 | ENST00000492957.1 | chr1_243612979_- | 176 | -177.00 | -172.50 | -195.10 |
| ADediting_82993 | ENST00000492957.1 | chr1_243612987_- | 168 | -173.00 | -172.50 | -195.10 |
| ADediting_82994 | ENST00000492957.1 | chr1_243612993_- | 162 | -172.50 | -172.50 | -195.10 |
| ADediting_1518196 | ENST00000492957.1 | chr1_243612995_- | 160 | -172.50 | -172.50 | -195.10 |
| ADediting_82995 | ENST00000492957.1 | chr1_243612998_- | 157 | -173.30 | -172.50 | -195.10 |
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Relation with ADAR for AKT3 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Tissue | ADeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | ADediting_82992 | chr1_243612979_- | 0.0726131477790927 | 0.102109444619689 | 0.368047132173085 | 0.0512979324971694 | 4.08720863524291e-09 | 0.32613817333632 |
| Correlation between ADAR gene expression and this gene's expression |
| Tissue | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| DLPFC | 1.12089407592829e-19 | 0.484786987819222 | 5.5583553413784e-08 | 0.302505974809032 | 0.917125726808471 | 0.0059338443541735 |
| PCC | 3.45558449892306e-16 | 0.54529190264128 | 2.88813212458259e-14 | 0.513904681629834 | 0.122185707645654 | 0.112223409431811 |
| CER | 6.15196400464294e-61 | 0.916972930471772 | 2.94916069866018e-37 | 0.817292383505929 | 0.000113211877663849 | 0.30999125378423 |
| TCX | 4.64359013242968e-55 | 0.899414698482307 | 3.15094939771856e-28 | 0.748847685914156 | 0.874452626202698 | -0.0130093619437012 |
| FP | 9.91256881568163e-17 | 0.570091415983051 | 2.33555878269302e-14 | 0.531350515991538 | 0.636376313315842 | -0.0356757724519492 |
| IFG | 0.00253841290924376 | 0.576854300877733 | 0.108606174909249 | 0.328736183044867 | 0.33553894877284 | -0.200915881738789 |
| PG | 5.62432417481673e-43 | 0.801644655064814 | 7.36179384622484e-25 | 0.662385179193269 | 0.433521049931511 | -0.0577670396785357 |
| STG | 1.08753142815535e-18 | 0.78440455689052 | 4.8709608509892e-14 | 0.708268852570397 | 0.830457895324345 | -0.0237138313223345 |
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Relation with AD stages for AKT3 |
| Correlation between AD stages and RNA editing frequency |
| Tissue | ADeditomID | position | P-val | Coeff. |
| Correlation between AD stages and this gene's expression |
| Tissue | P-val | Coeff. |
| CER | 5.56925926761507e-06 | 0.421433011592251 |
| STG | 0.00350156099082846 | -0.315147390387349 |
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RelatedDrugs for AKT3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AKT3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| AKT3 | C0020255 | Hydrocephalus | 4 | GENOMICS_ENGLAND |
| AKT3 | C4014738 | MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2 | 4 | UNIPROT |
| AKT3 | C3714756 | Intellectual Disability | 2 | GENOMICS_ENGLAND |
| AKT3 | C0431380 | Cortical Dysplasia | 1 | CTD_human |
| AKT3 | C1863924 | Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 1 | CTD_human;ORPHANET |
| AKT3 | C1955869 | Malformations of Cortical Development | 1 | CTD_human;GENOMICS_ENGLAND |
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